IMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER

C1q- and C3d-IC, were determined in patients with posttraumatic stress disorder (PTSD), as compared to healthy subjects, using an enzyme-linked immunosorbent assay. According to the data obtained, the levels of both C1q- и C3d-IC were significantly increased in PTSD-patients versus healthy subjects,...

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Autores principales:	L. P. Hovhannisyan, A. S. Boyajyan, G. M. Mkrtchyan, S. H. Sukiasyan, V. A. Ayvazyan, M. S. Petrosyan, K. K. Harutyunyan, R. I. Musaelian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	c1q- и c3d immune complexes immune system chronic activation posttraumatic stress disorder systemic inflammation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/17bab0e64e8d442691733372465bab1e
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spelling	oai:doaj.org-article:17bab0e64e8d442691733372465bab1e2021-11-18T08:03:43ZIMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER1563-06252313-741X10.15789/1563-0625-2012-6-545-548https://doaj.org/article/17bab0e64e8d442691733372465bab1e2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/637https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XC1q- and C3d-IC, were determined in patients with posttraumatic stress disorder (PTSD), as compared to healthy subjects, using an enzyme-linked immunosorbent assay. According to the data obtained, the levels of both C1q- и C3d-IC were significantly increased in PTSD-patients versus healthy subjects, thus reflecting hyperactivation of classical complement pathway detected in this pathology. Moreover, a significant positive correlation was found between C1q- and C3d-IC levels in PTSD group. It was concluded that PTSD is characterized by altered mechanisms of IC recognition and elimination that may underly chronic activation of immune system and systemic inflammatory response associated with this disorder.L. P. HovhannisyanA. S. BoyajyanG. M. MkrtchyanS. H. SukiasyanV. A. AyvazyanM. S. PetrosyanK. K. HarutyunyanR. I. MusaelianSPb RAACIarticlec1q- и c3d immune complexesimmune systemchronic activationposttraumatic stress disordersystemic inflammationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 6, Pp 545-548 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	c1q- и c3d immune complexes immune system chronic activation posttraumatic stress disorder systemic inflammation Immunologic diseases. Allergy RC581-607
spellingShingle	c1q- и c3d immune complexes immune system chronic activation posttraumatic stress disorder systemic inflammation Immunologic diseases. Allergy RC581-607 L. P. Hovhannisyan A. S. Boyajyan G. M. Mkrtchyan S. H. Sukiasyan V. A. Ayvazyan M. S. Petrosyan K. K. Harutyunyan R. I. Musaelian IMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER
description	C1q- and C3d-IC, were determined in patients with posttraumatic stress disorder (PTSD), as compared to healthy subjects, using an enzyme-linked immunosorbent assay. According to the data obtained, the levels of both C1q- и C3d-IC were significantly increased in PTSD-patients versus healthy subjects, thus reflecting hyperactivation of classical complement pathway detected in this pathology. Moreover, a significant positive correlation was found between C1q- and C3d-IC levels in PTSD group. It was concluded that PTSD is characterized by altered mechanisms of IC recognition and elimination that may underly chronic activation of immune system and systemic inflammatory response associated with this disorder.
format	article
author	L. P. Hovhannisyan A. S. Boyajyan G. M. Mkrtchyan S. H. Sukiasyan V. A. Ayvazyan M. S. Petrosyan K. K. Harutyunyan R. I. Musaelian
author_facet	L. P. Hovhannisyan A. S. Boyajyan G. M. Mkrtchyan S. H. Sukiasyan V. A. Ayvazyan M. S. Petrosyan K. K. Harutyunyan R. I. Musaelian
author_sort	L. P. Hovhannisyan
title	IMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER
title_short	IMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER
title_full	IMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER
title_fullStr	IMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER
title_full_unstemmed	IMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER
title_sort	immune complexes as indices of chronic inflammation accompanying posttraumatic stress disorder
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/17bab0e64e8d442691733372465bab1e
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IMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER

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