Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis

GM-CSF is involved in control over M. tuberculosis infection. Here the authors show that GM-CSF reduces type 1 interferon driven neutrophil recruitment, NETosis and bacterial growth in the lungs of infected mice, and provide evidence that this NETosis occurs in infected humans who are not responsive...

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Autores principales:	Lúcia Moreira-Teixeira, Philippa J. Stimpson, Evangelos Stavropoulos, Sabelo Hadebe, Probir Chakravarty, Marianna Ioannou, Iker Valle Aramburu, Eleanor Herbert, Simon L. Priestnall, Alejandro Suarez-Bonnet, Jeremy Sousa, Kaori L. Fonseca, Qian Wang, Sergo Vashakidze, Paula Rodríguez-Martínez, Cristina Vilaplana, Margarida Saraiva, Venizelos Papayannopoulos, Anne O’Garra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17bb66cf20aa478d882dee5a8fe9ffd3
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spelling	oai:doaj.org-article:17bb66cf20aa478d882dee5a8fe9ffd32021-12-02T14:41:04ZType I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis10.1038/s41467-020-19412-62041-1723https://doaj.org/article/17bb66cf20aa478d882dee5a8fe9ffd32020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19412-6https://doaj.org/toc/2041-1723GM-CSF is involved in control over M. tuberculosis infection. Here the authors show that GM-CSF reduces type 1 interferon driven neutrophil recruitment, NETosis and bacterial growth in the lungs of infected mice, and provide evidence that this NETosis occurs in infected humans who are not responsive to antibiotic therapy.Lúcia Moreira-TeixeiraPhilippa J. StimpsonEvangelos StavropoulosSabelo HadebeProbir ChakravartyMarianna IoannouIker Valle AramburuEleanor HerbertSimon L. PriestnallAlejandro Suarez-BonnetJeremy SousaKaori L. FonsecaQian WangSergo VashakidzePaula Rodríguez-MartínezCristina VilaplanaMargarida SaraivaVenizelos PapayannopoulosAnne O’GarraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lúcia Moreira-Teixeira Philippa J. Stimpson Evangelos Stavropoulos Sabelo Hadebe Probir Chakravarty Marianna Ioannou Iker Valle Aramburu Eleanor Herbert Simon L. Priestnall Alejandro Suarez-Bonnet Jeremy Sousa Kaori L. Fonseca Qian Wang Sergo Vashakidze Paula Rodríguez-Martínez Cristina Vilaplana Margarida Saraiva Venizelos Papayannopoulos Anne O’Garra Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
description	GM-CSF is involved in control over M. tuberculosis infection. Here the authors show that GM-CSF reduces type 1 interferon driven neutrophil recruitment, NETosis and bacterial growth in the lungs of infected mice, and provide evidence that this NETosis occurs in infected humans who are not responsive to antibiotic therapy.
format	article
author	Lúcia Moreira-Teixeira Philippa J. Stimpson Evangelos Stavropoulos Sabelo Hadebe Probir Chakravarty Marianna Ioannou Iker Valle Aramburu Eleanor Herbert Simon L. Priestnall Alejandro Suarez-Bonnet Jeremy Sousa Kaori L. Fonseca Qian Wang Sergo Vashakidze Paula Rodríguez-Martínez Cristina Vilaplana Margarida Saraiva Venizelos Papayannopoulos Anne O’Garra
author_facet	Lúcia Moreira-Teixeira Philippa J. Stimpson Evangelos Stavropoulos Sabelo Hadebe Probir Chakravarty Marianna Ioannou Iker Valle Aramburu Eleanor Herbert Simon L. Priestnall Alejandro Suarez-Bonnet Jeremy Sousa Kaori L. Fonseca Qian Wang Sergo Vashakidze Paula Rodríguez-Martínez Cristina Vilaplana Margarida Saraiva Venizelos Papayannopoulos Anne O’Garra
author_sort	Lúcia Moreira-Teixeira
title	Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
title_short	Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
title_full	Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
title_fullStr	Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
title_full_unstemmed	Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
title_sort	type i ifn exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and netosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/17bb66cf20aa478d882dee5a8fe9ffd3
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Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis

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