FDG PET/CT and Colonoscopy Combine Synergistically in Colorectal Cancer Primary Diagnosis.

Aim: Colonoscopy is the standard for primary colorectal cancer (CRC) detection, but is invasive and imperfect. The aim of this study was to assess the accuracy of 18F-fluorodeoxyglucose (FDG) Positron emission tomography/Computed tomography (PET/CT) and colonoscopy in the diagnosis of primary CRC. M...

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Autores principales:	Doruk Seyfi, Chuong Bui, Walid Barto, Assad Zahid, Christopher Young
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	18f-fluorodeoxyglucose positron emission tomography computed tomography colonoscopy colorectal cancer Medicine R
Acceso en línea:	https://doaj.org/article/17bc4c1fe19b4a83b70e3b4c8b1d160e
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spelling	oai:doaj.org-article:17bc4c1fe19b4a83b70e3b4c8b1d160e2021-11-14T06:50:42ZFDG PET/CT and Colonoscopy Combine Synergistically in Colorectal Cancer Primary Diagnosis.2783-243010.30476/acrr.2021.91044.1095https://doaj.org/article/17bc4c1fe19b4a83b70e3b4c8b1d160e2021-06-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_47639_481dd9d07c62df9994a4b5dab965a4e3.pdfhttps://doaj.org/toc/2783-2430Aim: Colonoscopy is the standard for primary colorectal cancer (CRC) detection, but is invasive and imperfect. The aim of this study was to assess the accuracy of 18F-fluorodeoxyglucose (FDG) Positron emission tomography/Computed tomography (PET/CT) and colonoscopy in the diagnosis of primary CRC. Methods: A retrospective analysis of all patients identified as undergoing a FDG PET/CT scan and a colonoscopy within six months of each other, with no intervening malignancy treatment, over a 12 month period in a single University teaching hospital. Results: Two hundred and sixty-two patients had FDG PET/CT and colonoscopy within 6 months. 206 were excluded for prior treatment. 56 patients were included, 26 (46%) with confirmed primary CRC tumors and 30 (54%) without. Multivariate logistic regression analysis indicated that CRC diagnosis was more likely when colonoscopy was performed before the FDG PET/CT (Odds Ratio (OR) 21.9 (CI 2.6-183) and when CRC was diagnosed on FDG PET/CT (OR 12.3 (CI 3.0-51.0). The ROC-AUC for FDG PET/CT and colonoscopy was 0.81 (CI 0.70-0.93, p <0.001) and 0.96 (CI 0.90-1.0, p <0.001) respectively. Conclusions: Colonoscopy is very good and FDG PET/CT is good as diagnostic tests for CRC primary diagnosis. Together they facilitated diagnosis in all CRC primaries. PET/CT should be considered in patients’ with incomplete colonoscopy where there is suspicion for CRC primary.Doruk SeyfiChuong BuiWalid BartoAssad ZahidChristopher YoungShiraz University of Medical Sciencesarticle18f-fluorodeoxyglucosepositron emission tomographycomputed tomographycolonoscopycolorectal cancerMedicineRENIranian Journal of Colorectal Research, Vol 9, Iss 2, Pp 58-62 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	18f-fluorodeoxyglucose positron emission tomography computed tomography colonoscopy colorectal cancer Medicine R
spellingShingle	18f-fluorodeoxyglucose positron emission tomography computed tomography colonoscopy colorectal cancer Medicine R Doruk Seyfi Chuong Bui Walid Barto Assad Zahid Christopher Young FDG PET/CT and Colonoscopy Combine Synergistically in Colorectal Cancer Primary Diagnosis.
description	Aim: Colonoscopy is the standard for primary colorectal cancer (CRC) detection, but is invasive and imperfect. The aim of this study was to assess the accuracy of 18F-fluorodeoxyglucose (FDG) Positron emission tomography/Computed tomography (PET/CT) and colonoscopy in the diagnosis of primary CRC. Methods: A retrospective analysis of all patients identified as undergoing a FDG PET/CT scan and a colonoscopy within six months of each other, with no intervening malignancy treatment, over a 12 month period in a single University teaching hospital. Results: Two hundred and sixty-two patients had FDG PET/CT and colonoscopy within 6 months. 206 were excluded for prior treatment. 56 patients were included, 26 (46%) with confirmed primary CRC tumors and 30 (54%) without. Multivariate logistic regression analysis indicated that CRC diagnosis was more likely when colonoscopy was performed before the FDG PET/CT (Odds Ratio (OR) 21.9 (CI 2.6-183) and when CRC was diagnosed on FDG PET/CT (OR 12.3 (CI 3.0-51.0). The ROC-AUC for FDG PET/CT and colonoscopy was 0.81 (CI 0.70-0.93, p <0.001) and 0.96 (CI 0.90-1.0, p <0.001) respectively. Conclusions: Colonoscopy is very good and FDG PET/CT is good as diagnostic tests for CRC primary diagnosis. Together they facilitated diagnosis in all CRC primaries. PET/CT should be considered in patients’ with incomplete colonoscopy where there is suspicion for CRC primary.
format	article
author	Doruk Seyfi Chuong Bui Walid Barto Assad Zahid Christopher Young
author_facet	Doruk Seyfi Chuong Bui Walid Barto Assad Zahid Christopher Young
author_sort	Doruk Seyfi
title	FDG PET/CT and Colonoscopy Combine Synergistically in Colorectal Cancer Primary Diagnosis.
title_short	FDG PET/CT and Colonoscopy Combine Synergistically in Colorectal Cancer Primary Diagnosis.
title_full	FDG PET/CT and Colonoscopy Combine Synergistically in Colorectal Cancer Primary Diagnosis.
title_fullStr	FDG PET/CT and Colonoscopy Combine Synergistically in Colorectal Cancer Primary Diagnosis.
title_full_unstemmed	FDG PET/CT and Colonoscopy Combine Synergistically in Colorectal Cancer Primary Diagnosis.
title_sort	fdg pet/ct and colonoscopy combine synergistically in colorectal cancer primary diagnosis.
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/17bc4c1fe19b4a83b70e3b4c8b1d160e
work_keys_str_mv	AT dorukseyfi fdgpetctandcolonoscopycombinesynergisticallyincolorectalcancerprimarydiagnosis AT chuongbui fdgpetctandcolonoscopycombinesynergisticallyincolorectalcancerprimarydiagnosis AT walidbarto fdgpetctandcolonoscopycombinesynergisticallyincolorectalcancerprimarydiagnosis AT assadzahid fdgpetctandcolonoscopycombinesynergisticallyincolorectalcancerprimarydiagnosis AT christopheryoung fdgpetctandcolonoscopycombinesynergisticallyincolorectalcancerprimarydiagnosis
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FDG PET/CT and Colonoscopy Combine Synergistically in Colorectal Cancer Primary Diagnosis.

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