A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a <i>Streptomyces</i> Strain Collection Isolated from Leaf-Cutting Ants

The rapid emergence of bacterial resistance to antibiotics has urged the need to find novel bioactive compounds against resistant microorganisms. For that purpose, different strategies are being followed, one of them being exploring secondary metabolite production in microorganisms from uncommon sou...

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Autores principales:	Ana Ceniceros, Lorena Cuervo, Carmen Méndez, José A. Salas, Carlos Olano, Mónica G. Malmierca
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Streptomyces</i> secondary metabolites biosynthetic potential gene clusters bioinformatics Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/17bd718a8a9f4eff99e864064f31a0d7
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spelling	oai:doaj.org-article:17bd718a8a9f4eff99e864064f31a0d72021-11-25T18:24:22ZA Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a <i>Streptomyces</i> Strain Collection Isolated from Leaf-Cutting Ants10.3390/microorganisms91122252076-2607https://doaj.org/article/17bd718a8a9f4eff99e864064f31a0d72021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2225https://doaj.org/toc/2076-2607The rapid emergence of bacterial resistance to antibiotics has urged the need to find novel bioactive compounds against resistant microorganisms. For that purpose, different strategies are being followed, one of them being exploring secondary metabolite production in microorganisms from uncommon sources. In this work, we have analyzed the genome of 12 <i>Streptomyces</i> sp. strains of the CS collection isolated from the surface of leaf-cutting ants of the <i>Attini</i> tribe and compared them to four <i>Streptomyces</i> model species and <i>Pseudonocardia</i> sp. Ae150A_Ps1, which shares the ecological niche with those of the CS collection. We used a combination of phylogenetics, bioinformatics and dereplication analysis to study the biosynthetic potential of our strains. 51.5% of the biosynthetic gene clusters (BGCs) predicted by antiSMASH were unknown and over half of them were strain-specific, making this strain collection an interesting source of putative novel compounds.Ana CenicerosLorena CuervoCarmen MéndezJosé A. SalasCarlos OlanoMónica G. MalmiercaMDPI AGarticle<i>Streptomyces</i>secondary metabolitesbiosynthetic potentialgene clustersbioinformaticsBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2225, p 2225 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Streptomyces</i> secondary metabolites biosynthetic potential gene clusters bioinformatics Biology (General) QH301-705.5
spellingShingle	<i>Streptomyces</i> secondary metabolites biosynthetic potential gene clusters bioinformatics Biology (General) QH301-705.5 Ana Ceniceros Lorena Cuervo Carmen Méndez José A. Salas Carlos Olano Mónica G. Malmierca A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a <i>Streptomyces</i> Strain Collection Isolated from Leaf-Cutting Ants
description	The rapid emergence of bacterial resistance to antibiotics has urged the need to find novel bioactive compounds against resistant microorganisms. For that purpose, different strategies are being followed, one of them being exploring secondary metabolite production in microorganisms from uncommon sources. In this work, we have analyzed the genome of 12 <i>Streptomyces</i> sp. strains of the CS collection isolated from the surface of leaf-cutting ants of the <i>Attini</i> tribe and compared them to four <i>Streptomyces</i> model species and <i>Pseudonocardia</i> sp. Ae150A_Ps1, which shares the ecological niche with those of the CS collection. We used a combination of phylogenetics, bioinformatics and dereplication analysis to study the biosynthetic potential of our strains. 51.5% of the biosynthetic gene clusters (BGCs) predicted by antiSMASH were unknown and over half of them were strain-specific, making this strain collection an interesting source of putative novel compounds.
format	article
author	Ana Ceniceros Lorena Cuervo Carmen Méndez José A. Salas Carlos Olano Mónica G. Malmierca
author_facet	Ana Ceniceros Lorena Cuervo Carmen Méndez José A. Salas Carlos Olano Mónica G. Malmierca
author_sort	Ana Ceniceros
title	A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a <i>Streptomyces</i> Strain Collection Isolated from Leaf-Cutting Ants
title_short	A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a <i>Streptomyces</i> Strain Collection Isolated from Leaf-Cutting Ants
title_full	A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a <i>Streptomyces</i> Strain Collection Isolated from Leaf-Cutting Ants
title_fullStr	A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a <i>Streptomyces</i> Strain Collection Isolated from Leaf-Cutting Ants
title_full_unstemmed	A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a <i>Streptomyces</i> Strain Collection Isolated from Leaf-Cutting Ants
title_sort	multidisciplinary approach to unraveling the natural product biosynthetic potential of a <i>streptomyces</i> strain collection isolated from leaf-cutting ants
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/17bd718a8a9f4eff99e864064f31a0d7
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A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a <i>Streptomyces</i> Strain Collection Isolated from Leaf-Cutting Ants

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