Two Novel Semisynthetic Lipoglycopeptides Active against <i>Staphylococcus aureus</i> Biofilms and Cells in Late Stationary Growth Phase

The increase in antibiotic resistance among Gram-positive bacteria underscores the urgent need to develop new antibiotics. New antibiotics should target actively growing susceptible bacteria that are resistant to clinically accepted antibiotics including bacteria that are not growing or are protecte...

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Autores principales:	Vladimir Vimberg, Leona Zieglerova, Aninda Mazumdar, Zsolt Szűcs, Aniko Borbás, Pál Herczegh, Gabriela Balikova Novotna
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antibiotic resistance glycopeptide antibiotics <i>Staphylococcus aureus</i> teicoplanin pseudoaglycon Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/17c1c0e3cb234f2b884059fda98a0fcd
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spelling	oai:doaj.org-article:17c1c0e3cb234f2b884059fda98a0fcd2021-11-25T18:40:00ZTwo Novel Semisynthetic Lipoglycopeptides Active against <i>Staphylococcus aureus</i> Biofilms and Cells in Late Stationary Growth Phase10.3390/ph141111821424-8247https://doaj.org/article/17c1c0e3cb234f2b884059fda98a0fcd2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1182https://doaj.org/toc/1424-8247The increase in antibiotic resistance among Gram-positive bacteria underscores the urgent need to develop new antibiotics. New antibiotics should target actively growing susceptible bacteria that are resistant to clinically accepted antibiotics including bacteria that are not growing or are protected in a biofilm environment. In this paper, we compare the in vitro activities of two new semisynthetic glycopeptide antibiotics, MA79 and ERJ390, with two clinically used glycopeptide antibiotics—vancomycin and teicoplanin. The new antibiotics effectively killed not only exponentially growing cells of <i>Staphylococcus aureus</i>, but also cells in the stationary growth phase and biofilm.Vladimir VimbergLeona ZieglerovaAninda MazumdarZsolt SzűcsAniko BorbásPál HerczeghGabriela Balikova NovotnaMDPI AGarticleantibiotic resistanceglycopeptide antibiotics<i>Staphylococcus aureus</i>teicoplanin pseudoaglyconMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1182, p 1182 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic resistance glycopeptide antibiotics <i>Staphylococcus aureus</i> teicoplanin pseudoaglycon Medicine R Pharmacy and materia medica RS1-441
spellingShingle	antibiotic resistance glycopeptide antibiotics <i>Staphylococcus aureus</i> teicoplanin pseudoaglycon Medicine R Pharmacy and materia medica RS1-441 Vladimir Vimberg Leona Zieglerova Aninda Mazumdar Zsolt Szűcs Aniko Borbás Pál Herczegh Gabriela Balikova Novotna Two Novel Semisynthetic Lipoglycopeptides Active against <i>Staphylococcus aureus</i> Biofilms and Cells in Late Stationary Growth Phase
description	The increase in antibiotic resistance among Gram-positive bacteria underscores the urgent need to develop new antibiotics. New antibiotics should target actively growing susceptible bacteria that are resistant to clinically accepted antibiotics including bacteria that are not growing or are protected in a biofilm environment. In this paper, we compare the in vitro activities of two new semisynthetic glycopeptide antibiotics, MA79 and ERJ390, with two clinically used glycopeptide antibiotics—vancomycin and teicoplanin. The new antibiotics effectively killed not only exponentially growing cells of <i>Staphylococcus aureus</i>, but also cells in the stationary growth phase and biofilm.
format	article
author	Vladimir Vimberg Leona Zieglerova Aninda Mazumdar Zsolt Szűcs Aniko Borbás Pál Herczegh Gabriela Balikova Novotna
author_facet	Vladimir Vimberg Leona Zieglerova Aninda Mazumdar Zsolt Szűcs Aniko Borbás Pál Herczegh Gabriela Balikova Novotna
author_sort	Vladimir Vimberg
title	Two Novel Semisynthetic Lipoglycopeptides Active against <i>Staphylococcus aureus</i> Biofilms and Cells in Late Stationary Growth Phase
title_short	Two Novel Semisynthetic Lipoglycopeptides Active against <i>Staphylococcus aureus</i> Biofilms and Cells in Late Stationary Growth Phase
title_full	Two Novel Semisynthetic Lipoglycopeptides Active against <i>Staphylococcus aureus</i> Biofilms and Cells in Late Stationary Growth Phase
title_fullStr	Two Novel Semisynthetic Lipoglycopeptides Active against <i>Staphylococcus aureus</i> Biofilms and Cells in Late Stationary Growth Phase
title_full_unstemmed	Two Novel Semisynthetic Lipoglycopeptides Active against <i>Staphylococcus aureus</i> Biofilms and Cells in Late Stationary Growth Phase
title_sort	two novel semisynthetic lipoglycopeptides active against <i>staphylococcus aureus</i> biofilms and cells in late stationary growth phase
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/17c1c0e3cb234f2b884059fda98a0fcd
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Two Novel Semisynthetic Lipoglycopeptides Active against <i>Staphylococcus aureus</i> Biofilms and Cells in Late Stationary Growth Phase

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