Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo

Ming-Chen Sun,1,* Xiao-Ling Xu,1,* Xue-Fang Lou,2 Yong-Zhong Du1 1Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China; 2School of Medicine, Zhejiang University City College, Hangzhou 310015, People’s Rep...

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Autores principales:	Sun MC, Xu XL, Lou XF, Du YZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	vitiligo nano-drug delivery system transdermal penetration liposomes skin. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/17c1ccd132fc4aefa84f54ae11f50780
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spelling	oai:doaj.org-article:17c1ccd132fc4aefa84f54ae11f507802021-12-02T11:06:39ZRecent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo1178-2013https://doaj.org/article/17c1ccd132fc4aefa84f54ae11f507802020-05-01T00:00:00Zhttps://www.dovepress.com/recent-progress-and-future-directions-the-nano-drug-delivery-system-fo-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ming-Chen Sun,1,* Xiao-Ling Xu,1,* Xue-Fang Lou,2 Yong-Zhong Du1 1Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China; 2School of Medicine, Zhejiang University City College, Hangzhou 310015, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong-Zhong DuInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yu-Hang-Tang Road, Hangzhou 310058, People’s Republic of ChinaTel +86-571-88208435Fax +86-571-88208439Email duyongzhong@zju.edu.cnXue-Fang LouSchool of Medicine, Zhejiang University City College, 51 Hu-Zhou Street, Hangzhou 310015, People’s Republic of ChinaTel +86-571-88013011Fax +86-571-88018442Email louxf@zucc.edu.cnAbstract: Vitiligo is a depigmentation disease that seriously affects the physical health, mental health and quality of life of a patient. Therapeutic aim at control immunoreaction by relieving oxidative stress. Unfortunately, the cuticle barrier function and lack of specific accumulation lead to unsatisfactory therapeutic outcomes and side effects. The introduction and innovation of nanotechnology offers inspiration and clues for the development of new strategies to treat vitiligo. However, not many studies have been done to interrogate how nanotechnology can be used for vitiligo treatment. In this review, we summarize and analyze recent studies involving nano-drug delivery systems for the treatment of vitiligo, with a special emphasis on liposomes, niosomes, nanohydrogel and nanoparticles. These studies made significant progress by either increasing drug loading efficiency or enhancing penetration. Based on these studies, there are three proposed principles for topical nano-drug delivery systems treatment of vitiligo including the promotion of transdermal penetration, enhancement of drug retention and facilitation of melanin regeneration. The presentation of these ideas may provide inspirations for the future development of topical drug delivery systems that will conquer vitiligo.Keywords: vitiligo, nano-drug delivery system, transdermal penetration, liposomes, skinSun MCXu XLLou XFDu YZDove Medical Pressarticlevitiligonano-drug delivery systemtransdermal penetrationliposomesskin.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 3267-3279 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitiligo nano-drug delivery system transdermal penetration liposomes skin. Medicine (General) R5-920
spellingShingle	vitiligo nano-drug delivery system transdermal penetration liposomes skin. Medicine (General) R5-920 Sun MC Xu XL Lou XF Du YZ Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo
description	Ming-Chen Sun,1,* Xiao-Ling Xu,1,* Xue-Fang Lou,2 Yong-Zhong Du1 1Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China; 2School of Medicine, Zhejiang University City College, Hangzhou 310015, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong-Zhong DuInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yu-Hang-Tang Road, Hangzhou 310058, People’s Republic of ChinaTel +86-571-88208435Fax +86-571-88208439Email duyongzhong@zju.edu.cnXue-Fang LouSchool of Medicine, Zhejiang University City College, 51 Hu-Zhou Street, Hangzhou 310015, People’s Republic of ChinaTel +86-571-88013011Fax +86-571-88018442Email louxf@zucc.edu.cnAbstract: Vitiligo is a depigmentation disease that seriously affects the physical health, mental health and quality of life of a patient. Therapeutic aim at control immunoreaction by relieving oxidative stress. Unfortunately, the cuticle barrier function and lack of specific accumulation lead to unsatisfactory therapeutic outcomes and side effects. The introduction and innovation of nanotechnology offers inspiration and clues for the development of new strategies to treat vitiligo. However, not many studies have been done to interrogate how nanotechnology can be used for vitiligo treatment. In this review, we summarize and analyze recent studies involving nano-drug delivery systems for the treatment of vitiligo, with a special emphasis on liposomes, niosomes, nanohydrogel and nanoparticles. These studies made significant progress by either increasing drug loading efficiency or enhancing penetration. Based on these studies, there are three proposed principles for topical nano-drug delivery systems treatment of vitiligo including the promotion of transdermal penetration, enhancement of drug retention and facilitation of melanin regeneration. The presentation of these ideas may provide inspirations for the future development of topical drug delivery systems that will conquer vitiligo.Keywords: vitiligo, nano-drug delivery system, transdermal penetration, liposomes, skin
format	article
author	Sun MC Xu XL Lou XF Du YZ
author_facet	Sun MC Xu XL Lou XF Du YZ
author_sort	Sun MC
title	Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo
title_short	Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo
title_full	Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo
title_fullStr	Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo
title_full_unstemmed	Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo
title_sort	recent progress and future directions: the nano-drug delivery system for the treatment of vitiligo
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/17c1ccd132fc4aefa84f54ae11f50780
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Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo

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