BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and glomerulonephritis in rats.

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Autores principales:	Adonia E. Papathanassiu, Jeong-Hun Ko, Martha Imprialou, Marta Bagnati, Prashant K. Srivastava, Hong A. Vu, Danilo Cucchi, Stephen P. McAdoo, Elitsa A. Ananieva, Claudio Mauro, Jacques Behmoaras
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17c2e0ed5041454ca875e7539e4aa551
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spelling	oai:doaj.org-article:17c2e0ed5041454ca875e7539e4aa5512021-12-02T14:41:10ZBCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases10.1038/ncomms160402041-1723https://doaj.org/article/17c2e0ed5041454ca875e7539e4aa5512017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16040https://doaj.org/toc/2041-1723BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and glomerulonephritis in rats.Adonia E. PapathanassiuJeong-Hun KoMartha ImprialouMarta BagnatiPrashant K. SrivastavaHong A. VuDanilo CucchiStephen P. McAdooElitsa A. AnanievaClaudio MauroJacques BehmoarasNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adonia E. Papathanassiu Jeong-Hun Ko Martha Imprialou Marta Bagnati Prashant K. Srivastava Hong A. Vu Danilo Cucchi Stephen P. McAdoo Elitsa A. Ananieva Claudio Mauro Jacques Behmoaras BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases
description	BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and glomerulonephritis in rats.
format	article
author	Adonia E. Papathanassiu Jeong-Hun Ko Martha Imprialou Marta Bagnati Prashant K. Srivastava Hong A. Vu Danilo Cucchi Stephen P. McAdoo Elitsa A. Ananieva Claudio Mauro Jacques Behmoaras
author_facet	Adonia E. Papathanassiu Jeong-Hun Ko Martha Imprialou Marta Bagnati Prashant K. Srivastava Hong A. Vu Danilo Cucchi Stephen P. McAdoo Elitsa A. Ananieva Claudio Mauro Jacques Behmoaras
author_sort	Adonia E. Papathanassiu
title	BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases
title_short	BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases
title_full	BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases
title_fullStr	BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases
title_full_unstemmed	BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases
title_sort	bcat1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/17c2e0ed5041454ca875e7539e4aa551
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BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

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