Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the disease in mice.
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Nature Portfolio
2017
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oai:doaj.org-article:17c58ccb118041e9a3a369a75450a6692021-12-02T13:57:54ZActivated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells10.1038/s41467-017-00169-42041-1723https://doaj.org/article/17c58ccb118041e9a3a369a75450a6692017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00169-4https://doaj.org/toc/2041-1723Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the disease in mice.Satish RanjanAlexander GoihlShrey KohliIhsan GadiMandy PierauKhurrum ShahzadDheerendra GuptaFabian BockHongjie WangHaroon ShaikhThilo KähneDirk ReinholdUte BankAna C. ZenclussenJana NiemzTina M. SchnöderMonika Brunner-WeinzierlThomas FischerThomas KalinskiBurkhart SchravenThomas LuftJochen HuehnMichael NaumannFlorian H. HeidelBerend IsermannNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Satish Ranjan Alexander Goihl Shrey Kohli Ihsan Gadi Mandy Pierau Khurrum Shahzad Dheerendra Gupta Fabian Bock Hongjie Wang Haroon Shaikh Thilo Kähne Dirk Reinhold Ute Bank Ana C. Zenclussen Jana Niemz Tina M. Schnöder Monika Brunner-Weinzierl Thomas Fischer Thomas Kalinski Burkhart Schraven Thomas Luft Jochen Huehn Michael Naumann Florian H. Heidel Berend Isermann Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells |
| description |
Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the disease in mice. |
| format |
article |
| author |
Satish Ranjan Alexander Goihl Shrey Kohli Ihsan Gadi Mandy Pierau Khurrum Shahzad Dheerendra Gupta Fabian Bock Hongjie Wang Haroon Shaikh Thilo Kähne Dirk Reinhold Ute Bank Ana C. Zenclussen Jana Niemz Tina M. Schnöder Monika Brunner-Weinzierl Thomas Fischer Thomas Kalinski Burkhart Schraven Thomas Luft Jochen Huehn Michael Naumann Florian H. Heidel Berend Isermann |
| author_facet |
Satish Ranjan Alexander Goihl Shrey Kohli Ihsan Gadi Mandy Pierau Khurrum Shahzad Dheerendra Gupta Fabian Bock Hongjie Wang Haroon Shaikh Thilo Kähne Dirk Reinhold Ute Bank Ana C. Zenclussen Jana Niemz Tina M. Schnöder Monika Brunner-Weinzierl Thomas Fischer Thomas Kalinski Burkhart Schraven Thomas Luft Jochen Huehn Michael Naumann Florian H. Heidel Berend Isermann |
| author_sort |
Satish Ranjan |
| title |
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells |
| title_short |
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells |
| title_full |
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells |
| title_fullStr |
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells |
| title_full_unstemmed |
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells |
| title_sort |
activated protein c protects from gvhd via par2/par3 signalling in regulatory t-cells |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/17c58ccb118041e9a3a369a75450a669 |
| work_keys_str_mv |
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