Postconditioning as a method tissue survivability enhancement in ischemic damage

The article presents the present-day data on the phenomenon of ischemic myocardial postconditioning. It has been shown, that this phenomenon consists in protection of the heart from reperfusion damage by the means of short episodes of ischemia/reperfusion performed at the early stage after prolonged...

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Autores principales:	M. G. Shurygin, I. A. Shurygina, N. N. Dremina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	postconditioning ischemia myocardial infarction signal cascade Science Q
Acceso en línea:	https://doaj.org/article/17c5cd4aae7049bda3f8848a44629fbc
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id	oai:doaj.org-article:17c5cd4aae7049bda3f8848a44629fbc
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spelling	oai:doaj.org-article:17c5cd4aae7049bda3f8848a44629fbc2021-11-23T06:14:35ZPostconditioning as a method tissue survivability enhancement in ischemic damage2541-94202587-959610.12737/23030https://doaj.org/article/17c5cd4aae7049bda3f8848a44629fbc2016-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/265https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article presents the present-day data on the phenomenon of ischemic myocardial postconditioning. It has been shown, that this phenomenon consists in protection of the heart from reperfusion damage by the means of short episodes of ischemia/reperfusion performed at the early stage after prolonged ischemia. It is presented that postconditioning effect manifests in limiting the size of infarction and preserving endothelial function in the region exposed to ischemic injury. The article reports on the modern concept of role of various intracellular signal cascades in providing survival of the cell after the episode of ischemia/reperfusion. Much attention is given to changing in the state of pores localized in internal mitochondrial membrane as end links of realization of postconditioning effect. Prospects of clinical use of postconditioning are very optimistic due to the fact that application of different variants of preconditioning is limited because in most cases it is impossible to predict the time of occurrence of ischemic injury, whereas postconditioning may be used after prolonged ischemia.M. G. ShuryginI. A. ShuryginaN. N. DreminaScientific Сentre for Family Health and Human Reproduction Problemsarticlepostconditioningischemiamyocardial infarctionsignal cascadeScienceQRUActa Biomedica Scientifica, Vol 1, Iss 4, Pp 183-186 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	postconditioning ischemia myocardial infarction signal cascade Science Q
spellingShingle	postconditioning ischemia myocardial infarction signal cascade Science Q M. G. Shurygin I. A. Shurygina N. N. Dremina Postconditioning as a method tissue survivability enhancement in ischemic damage
description	The article presents the present-day data on the phenomenon of ischemic myocardial postconditioning. It has been shown, that this phenomenon consists in protection of the heart from reperfusion damage by the means of short episodes of ischemia/reperfusion performed at the early stage after prolonged ischemia. It is presented that postconditioning effect manifests in limiting the size of infarction and preserving endothelial function in the region exposed to ischemic injury. The article reports on the modern concept of role of various intracellular signal cascades in providing survival of the cell after the episode of ischemia/reperfusion. Much attention is given to changing in the state of pores localized in internal mitochondrial membrane as end links of realization of postconditioning effect. Prospects of clinical use of postconditioning are very optimistic due to the fact that application of different variants of preconditioning is limited because in most cases it is impossible to predict the time of occurrence of ischemic injury, whereas postconditioning may be used after prolonged ischemia.
format	article
author	M. G. Shurygin I. A. Shurygina N. N. Dremina
author_facet	M. G. Shurygin I. A. Shurygina N. N. Dremina
author_sort	M. G. Shurygin
title	Postconditioning as a method tissue survivability enhancement in ischemic damage
title_short	Postconditioning as a method tissue survivability enhancement in ischemic damage
title_full	Postconditioning as a method tissue survivability enhancement in ischemic damage
title_fullStr	Postconditioning as a method tissue survivability enhancement in ischemic damage
title_full_unstemmed	Postconditioning as a method tissue survivability enhancement in ischemic damage
title_sort	postconditioning as a method tissue survivability enhancement in ischemic damage
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/17c5cd4aae7049bda3f8848a44629fbc
work_keys_str_mv	AT mgshurygin postconditioningasamethodtissuesurvivabilityenhancementinischemicdamage AT iashurygina postconditioningasamethodtissuesurvivabilityenhancementinischemicdamage AT nndremina postconditioningasamethodtissuesurvivabilityenhancementinischemicdamage
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Postconditioning as a method tissue survivability enhancement in ischemic damage

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