Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19

The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that the disease has on the health of the infected...

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Autores principales:	Filippo Liviero, Manuela Campisi, Paola Mason, Sofia Pavanello
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	TRPV-1 SARS-CoV-2 COVID-19 SNPs pollution inflammation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/17c71cf3d5af46e687acea3391f47837
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spelling	oai:doaj.org-article:17c71cf3d5af46e687acea3391f478372021-11-04T05:12:40ZTransient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-192296-858X10.3389/fmed.2021.753819https://doaj.org/article/17c71cf3d5af46e687acea3391f478372021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.753819/fullhttps://doaj.org/toc/2296-858XThe battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that the disease has on the health of the infected. The discovery that S protein includes two ankyrin binding motifs (S-ARBMs) and that the transient receptor potential vanilloid subtype 1 (TRPV-1) cation channels contain these ankyrin repeat domains (TRPs-ARDs) suggest that TRPV-1, the most studied member of the TRPV channel family, can play a role in binding SARS-CoV-2. This hypothesis is strengthened by studies showing that other respiratory viruses bind the TRPV-1 on sensory nerves and epithelial cells in the airways. Furthermore, the pathophysiology in COVID-19 patients is similar to the effects generated by TRPV-1 stimulation. Lastly, treatment with agonists that down-regulate or inactivate TRPV-1 can have a beneficial action on impaired lung functions and clearance of infection. In this review, we explore the role of the TRPV-1 channel in the infection, susceptibility, pathogenesis, and treatment of COVID-19, with the aim of looking at novel strategies to control infection and mitigate symptoms, and trying to translate this knowledge into new preventive and therapeutic interventions.Filippo LivieroManuela CampisiPaola MasonSofia PavanelloFrontiers Media S.A.articleTRPV-1SARS-CoV-2COVID-19SNPspollutioninflammationMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TRPV-1 SARS-CoV-2 COVID-19 SNPs pollution inflammation Medicine (General) R5-920
spellingShingle	TRPV-1 SARS-CoV-2 COVID-19 SNPs pollution inflammation Medicine (General) R5-920 Filippo Liviero Manuela Campisi Paola Mason Sofia Pavanello Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19
description	The battle against the new coronavirus that continues to kill millions of people will be still long. Novel strategies are demanded to control infection, mitigate symptoms and treatment of COVID-19. This is even more imperative given the long sequels that the disease has on the health of the infected. The discovery that S protein includes two ankyrin binding motifs (S-ARBMs) and that the transient receptor potential vanilloid subtype 1 (TRPV-1) cation channels contain these ankyrin repeat domains (TRPs-ARDs) suggest that TRPV-1, the most studied member of the TRPV channel family, can play a role in binding SARS-CoV-2. This hypothesis is strengthened by studies showing that other respiratory viruses bind the TRPV-1 on sensory nerves and epithelial cells in the airways. Furthermore, the pathophysiology in COVID-19 patients is similar to the effects generated by TRPV-1 stimulation. Lastly, treatment with agonists that down-regulate or inactivate TRPV-1 can have a beneficial action on impaired lung functions and clearance of infection. In this review, we explore the role of the TRPV-1 channel in the infection, susceptibility, pathogenesis, and treatment of COVID-19, with the aim of looking at novel strategies to control infection and mitigate symptoms, and trying to translate this knowledge into new preventive and therapeutic interventions.
format	article
author	Filippo Liviero Manuela Campisi Paola Mason Sofia Pavanello
author_facet	Filippo Liviero Manuela Campisi Paola Mason Sofia Pavanello
author_sort	Filippo Liviero
title	Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19
title_short	Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19
title_full	Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19
title_fullStr	Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19
title_full_unstemmed	Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19
title_sort	transient receptor potential vanilloid subtype 1: potential role in infection, susceptibility, symptoms and treatment of covid-19
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/17c71cf3d5af46e687acea3391f47837
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Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19

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