Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7

The authors find that deletion from Schwann cells of an E3 ubiquitin ligase component called Fbxw7 leads to a phenotype reminiscent of myelination in the central nervous system where a single oligodendrocyte ensheaths multiple axons.

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Detalles Bibliográficos
Autores principales: Breanne L. Harty, Fernanda Coelho, Sarah E. Pease-Raissi, Amit Mogha, Sarah D. Ackerman, Amy L. Herbert, Robert W. Gereau, Judith P. Golden, David A. Lyons, Jonah R. Chan, Kelly R. Monk
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/17c998c1a86747189f3f8c1962a53a63
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Descripción
Sumario:The authors find that deletion from Schwann cells of an E3 ubiquitin ligase component called Fbxw7 leads to a phenotype reminiscent of myelination in the central nervous system where a single oligodendrocyte ensheaths multiple axons.