Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7

The authors find that deletion from Schwann cells of an E3 ubiquitin ligase component called Fbxw7 leads to a phenotype reminiscent of myelination in the central nervous system where a single oligodendrocyte ensheaths multiple axons.

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Autores principales: Breanne L. Harty, Fernanda Coelho, Sarah E. Pease-Raissi, Amit Mogha, Sarah D. Ackerman, Amy L. Herbert, Robert W. Gereau, Judith P. Golden, David A. Lyons, Jonah R. Chan, Kelly R. Monk
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/17c998c1a86747189f3f8c1962a53a63
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spelling oai:doaj.org-article:17c998c1a86747189f3f8c1962a53a632021-12-02T16:51:01ZMyelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw710.1038/s41467-019-10881-y2041-1723https://doaj.org/article/17c998c1a86747189f3f8c1962a53a632019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10881-yhttps://doaj.org/toc/2041-1723The authors find that deletion from Schwann cells of an E3 ubiquitin ligase component called Fbxw7 leads to a phenotype reminiscent of myelination in the central nervous system where a single oligodendrocyte ensheaths multiple axons.Breanne L. HartyFernanda CoelhoSarah E. Pease-RaissiAmit MoghaSarah D. AckermanAmy L. HerbertRobert W. GereauJudith P. GoldenDavid A. LyonsJonah R. ChanKelly R. MonkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Breanne L. Harty
Fernanda Coelho
Sarah E. Pease-Raissi
Amit Mogha
Sarah D. Ackerman
Amy L. Herbert
Robert W. Gereau
Judith P. Golden
David A. Lyons
Jonah R. Chan
Kelly R. Monk
Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7
description The authors find that deletion from Schwann cells of an E3 ubiquitin ligase component called Fbxw7 leads to a phenotype reminiscent of myelination in the central nervous system where a single oligodendrocyte ensheaths multiple axons.
format article
author Breanne L. Harty
Fernanda Coelho
Sarah E. Pease-Raissi
Amit Mogha
Sarah D. Ackerman
Amy L. Herbert
Robert W. Gereau
Judith P. Golden
David A. Lyons
Jonah R. Chan
Kelly R. Monk
author_facet Breanne L. Harty
Fernanda Coelho
Sarah E. Pease-Raissi
Amit Mogha
Sarah D. Ackerman
Amy L. Herbert
Robert W. Gereau
Judith P. Golden
David A. Lyons
Jonah R. Chan
Kelly R. Monk
author_sort Breanne L. Harty
title Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7
title_short Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7
title_full Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7
title_fullStr Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7
title_full_unstemmed Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7
title_sort myelinating schwann cells ensheath multiple axons in the absence of e3 ligase component fbxw7
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/17c998c1a86747189f3f8c1962a53a63
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