Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA

Extremely compact environments can inhibit protein interactions by preventing 3-dimensional diffusion. Here the authors show that an 11-amino acid long peptide can function as a ‘molecular sled’, able to transport cargo linearly along DNA to enable interactions.

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Detalles Bibliográficos
Autores principales: Walter F. Mangel, William J. McGrath, Kan Xiong, Vito Graziano, Paul C. Blainey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/17ca686a1607463e8cf9d6dac2de694a
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Descripción
Sumario:Extremely compact environments can inhibit protein interactions by preventing 3-dimensional diffusion. Here the authors show that an 11-amino acid long peptide can function as a ‘molecular sled’, able to transport cargo linearly along DNA to enable interactions.