Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA

Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA

Extremely compact environments can inhibit protein interactions by preventing 3-dimensional diffusion. Here the authors show that an 11-amino acid long peptide can function as a ‘molecular sled’, able to transport cargo linearly along DNA to enable interactions.

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Autores principales: Walter F. Mangel, William J. McGrath, Kan Xiong, Vito Graziano, Paul C. Blainey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/17ca686a1607463e8cf9d6dac2de694a
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spelling oai:doaj.org-article:17ca686a1607463e8cf9d6dac2de694a2021-12-02T15:33:49ZMolecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA10.1038/ncomms102022041-1723https://doaj.org/article/17ca686a1607463e8cf9d6dac2de694a2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10202https://doaj.org/toc/2041-1723Extremely compact environments can inhibit protein interactions by preventing 3-dimensional diffusion. Here the authors show that an 11-amino acid long peptide can function as a ‘molecular sled’, able to transport cargo linearly along DNA to enable interactions.Walter F. MangelWilliam J. McGrathKan XiongVito GrazianoPaul C. BlaineyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Walter F. Mangel
William J. McGrath
Kan Xiong
Vito Graziano
Paul C. Blainey
Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
description Extremely compact environments can inhibit protein interactions by preventing 3-dimensional diffusion. Here the authors show that an 11-amino acid long peptide can function as a ‘molecular sled’, able to transport cargo linearly along DNA to enable interactions.
format article
author Walter F. Mangel
William J. McGrath
Kan Xiong
Vito Graziano
Paul C. Blainey
author_facet Walter F. Mangel
William J. McGrath
Kan Xiong
Vito Graziano
Paul C. Blainey
author_sort Walter F. Mangel
title Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
title_short Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
title_full Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
title_fullStr Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
title_full_unstemmed Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
title_sort molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along dna
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/17ca686a1607463e8cf9d6dac2de694a
work_keys_str_mv AT walterfmangel molecularsledisanelevenaminoacidvehiclefacilitatingbiochemicalinteractionsviaslidingcomponentsalongdna
AT williamjmcgrath molecularsledisanelevenaminoacidvehiclefacilitatingbiochemicalinteractionsviaslidingcomponentsalongdna
AT kanxiong molecularsledisanelevenaminoacidvehiclefacilitatingbiochemicalinteractionsviaslidingcomponentsalongdna
AT vitograziano molecularsledisanelevenaminoacidvehiclefacilitatingbiochemicalinteractionsviaslidingcomponentsalongdna
AT paulcblainey molecularsledisanelevenaminoacidvehiclefacilitatingbiochemicalinteractionsviaslidingcomponentsalongdna
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