TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination

RNA viruses can be detected by immune cell pattern recognition receptors, such as RLRs, resulting in MAVS-TBK1-IRF3 signalling and production of antiviral type 1 interferons. Here the authors show that macrophage TRAF3-interacting protein 3 regulates this signalling pathway by interacting with TRAF3...

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Autores principales:	Meng Deng, Jason W. Tam, Lufei Wang, Kaixin Liang, Sirui Li, Lu Zhang, Haitao Guo, Xiaobo Luo, Yang Zhang, Alex Petrucelli, Beckley K. Davis, Brian J. Conti, W. June Brickey, Ching-Chang Ko, Yu L. Lei, Shaocong Sun, Jenny P. -Y. Ting
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17cacfe2c68542b2a667a747cf1f862c
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spelling	oai:doaj.org-article:17cacfe2c68542b2a667a747cf1f862c2021-12-02T17:32:58ZTRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination10.1038/s41467-020-16014-02041-1723https://doaj.org/article/17cacfe2c68542b2a667a747cf1f862c2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16014-0https://doaj.org/toc/2041-1723RNA viruses can be detected by immune cell pattern recognition receptors, such as RLRs, resulting in MAVS-TBK1-IRF3 signalling and production of antiviral type 1 interferons. Here the authors show that macrophage TRAF3-interacting protein 3 regulates this signalling pathway by interacting with TRAF3 and TBK1 to suppress interferon responses.Meng DengJason W. TamLufei WangKaixin LiangSirui LiLu ZhangHaitao GuoXiaobo LuoYang ZhangAlex PetrucelliBeckley K. DavisBrian J. ContiW. June BrickeyChing-Chang KoYu L. LeiShaocong SunJenny P. -Y. TingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meng Deng Jason W. Tam Lufei Wang Kaixin Liang Sirui Li Lu Zhang Haitao Guo Xiaobo Luo Yang Zhang Alex Petrucelli Beckley K. Davis Brian J. Conti W. June Brickey Ching-Chang Ko Yu L. Lei Shaocong Sun Jenny P. -Y. Ting TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination
description	RNA viruses can be detected by immune cell pattern recognition receptors, such as RLRs, resulting in MAVS-TBK1-IRF3 signalling and production of antiviral type 1 interferons. Here the authors show that macrophage TRAF3-interacting protein 3 regulates this signalling pathway by interacting with TRAF3 and TBK1 to suppress interferon responses.
format	article
author	Meng Deng Jason W. Tam Lufei Wang Kaixin Liang Sirui Li Lu Zhang Haitao Guo Xiaobo Luo Yang Zhang Alex Petrucelli Beckley K. Davis Brian J. Conti W. June Brickey Ching-Chang Ko Yu L. Lei Shaocong Sun Jenny P. -Y. Ting
author_facet	Meng Deng Jason W. Tam Lufei Wang Kaixin Liang Sirui Li Lu Zhang Haitao Guo Xiaobo Luo Yang Zhang Alex Petrucelli Beckley K. Davis Brian J. Conti W. June Brickey Ching-Chang Ko Yu L. Lei Shaocong Sun Jenny P. -Y. Ting
author_sort	Meng Deng
title	TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination
title_short	TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination
title_full	TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination
title_fullStr	TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination
title_full_unstemmed	TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination
title_sort	traf3ip3 negatively regulates cytosolic rna induced anti-viral signaling by promoting tbk1 k48 ubiquitination
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/17cacfe2c68542b2a667a747cf1f862c
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TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination

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