Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.

Dry eye syndrome (DES) is a complex, multifactorial, immune-associated disorder of the tear and ocular surface. DES with a high prevalence world over needs identification of potential biomarkers so as to understand not only the disease mechanism but also to identify drug targets. In this study we lo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Saijyothi Venkata Aluru, Shweta Agarwal, Bhaskar Srinivasan, Geetha Krishnan Iyer, Sivakumar M Rajappa, Utpal Tatu, Prema Padmanabhan, Nirmala Subramanian, Angayarkanni Narayanasamy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17ce128ce6f641a4a5919bbbfa490856
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:17ce128ce6f641a4a5919bbbfa490856
record_format	dspace
spelling	oai:doaj.org-article:17ce128ce6f641a4a5919bbbfa4908562021-11-18T08:04:41ZLacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.1932-620310.1371/journal.pone.0051979https://doaj.org/article/17ce128ce6f641a4a5919bbbfa4908562012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272196/?tool=EBIhttps://doaj.org/toc/1932-6203Dry eye syndrome (DES) is a complex, multifactorial, immune-associated disorder of the tear and ocular surface. DES with a high prevalence world over needs identification of potential biomarkers so as to understand not only the disease mechanism but also to identify drug targets. In this study we looked for differentially expressed proteins in tear samples of DES to arrive at characteristic biomarkers. As part of a prospective case-control study, tear specimen were collected using Schirmer strips from 129 dry eye cases and 73 age matched controls. 2D electrophoresis (2DE) and Differential gel electrophoresis (DIGE) was done to identify differentially expressed proteins. One of the differentially expressed protein in DES is lacrimal proline rich 4 protein (LPRR4). LPRR4 protein expression was quantified by enzyme immune sorbent assay (ELISA). LPRR4 was down regulated significantly in all types of dry eye cases, correlating with the disease severity as measured by clinical investigations. Further characterization of the protein is required to assess its therapeutic potential in DES.Saijyothi Venkata AluruShweta AgarwalBhaskar SrinivasanGeetha Krishnan IyerSivakumar M RajappaUtpal TatuPrema PadmanabhanNirmala SubramanianAngayarkanni NarayanasamyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51979 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saijyothi Venkata Aluru Shweta Agarwal Bhaskar Srinivasan Geetha Krishnan Iyer Sivakumar M Rajappa Utpal Tatu Prema Padmanabhan Nirmala Subramanian Angayarkanni Narayanasamy Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
description	Dry eye syndrome (DES) is a complex, multifactorial, immune-associated disorder of the tear and ocular surface. DES with a high prevalence world over needs identification of potential biomarkers so as to understand not only the disease mechanism but also to identify drug targets. In this study we looked for differentially expressed proteins in tear samples of DES to arrive at characteristic biomarkers. As part of a prospective case-control study, tear specimen were collected using Schirmer strips from 129 dry eye cases and 73 age matched controls. 2D electrophoresis (2DE) and Differential gel electrophoresis (DIGE) was done to identify differentially expressed proteins. One of the differentially expressed protein in DES is lacrimal proline rich 4 protein (LPRR4). LPRR4 protein expression was quantified by enzyme immune sorbent assay (ELISA). LPRR4 was down regulated significantly in all types of dry eye cases, correlating with the disease severity as measured by clinical investigations. Further characterization of the protein is required to assess its therapeutic potential in DES.
format	article
author	Saijyothi Venkata Aluru Shweta Agarwal Bhaskar Srinivasan Geetha Krishnan Iyer Sivakumar M Rajappa Utpal Tatu Prema Padmanabhan Nirmala Subramanian Angayarkanni Narayanasamy
author_facet	Saijyothi Venkata Aluru Shweta Agarwal Bhaskar Srinivasan Geetha Krishnan Iyer Sivakumar M Rajappa Utpal Tatu Prema Padmanabhan Nirmala Subramanian Angayarkanni Narayanasamy
author_sort	Saijyothi Venkata Aluru
title	Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
title_short	Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
title_full	Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
title_fullStr	Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
title_full_unstemmed	Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
title_sort	lacrimal proline rich 4 (lprr4) protein in the tear fluid is a potential biomarker of dry eye syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/17ce128ce6f641a4a5919bbbfa490856
work_keys_str_mv	AT saijyothivenkataaluru lacrimalprolinerich4lprr4proteininthetearfluidisapotentialbiomarkerofdryeyesyndrome AT shwetaagarwal lacrimalprolinerich4lprr4proteininthetearfluidisapotentialbiomarkerofdryeyesyndrome AT bhaskarsrinivasan lacrimalprolinerich4lprr4proteininthetearfluidisapotentialbiomarkerofdryeyesyndrome AT geethakrishnaniyer lacrimalprolinerich4lprr4proteininthetearfluidisapotentialbiomarkerofdryeyesyndrome AT sivakumarmrajappa lacrimalprolinerich4lprr4proteininthetearfluidisapotentialbiomarkerofdryeyesyndrome AT utpaltatu lacrimalprolinerich4lprr4proteininthetearfluidisapotentialbiomarkerofdryeyesyndrome AT premapadmanabhan lacrimalprolinerich4lprr4proteininthetearfluidisapotentialbiomarkerofdryeyesyndrome AT nirmalasubramanian lacrimalprolinerich4lprr4proteininthetearfluidisapotentialbiomarkerofdryeyesyndrome AT angayarkanninarayanasamy lacrimalprolinerich4lprr4proteininthetearfluidisapotentialbiomarkerofdryeyesyndrome
_version_	1718422213764317184

Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome.

Ejemplares similares