Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase
Type 2 topoisomerases alter DNA supercoiling by an ATP-dependent reaction involving DNA passage through a cleaved DNA duplex. Here the authors present the crystal structure of the ParE ATPase domains of S. pneumoniae topoisomerase IV, in complex with a captured DNA oligonucleotide.
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/17d01b766de84ee880df3e914677978c |
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| Sumario: | Type 2 topoisomerases alter DNA supercoiling by an ATP-dependent reaction involving DNA passage through a cleaved DNA duplex. Here the authors present the crystal structure of the ParE ATPase domains of S. pneumoniae topoisomerase IV, in complex with a captured DNA oligonucleotide. |
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