Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase

Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase

Type 2 topoisomerases alter DNA supercoiling by an ATP-dependent reaction involving DNA passage through a cleaved DNA duplex. Here the authors present the crystal structure of the ParE ATPase domains of S. pneumoniae topoisomerase IV, in complex with a captured DNA oligonucleotide.

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Bibliographic Details
Main Authors: Ivan Laponogov, Xiao-Su Pan, Dennis A. Veselkov, Galyna B. Skamrova, Trishant R. Umrekar, L. Mark Fisher, Mark R. Sanderson
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/17d01b766de84ee880df3e914677978c
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Summary:Type 2 topoisomerases alter DNA supercoiling by an ATP-dependent reaction involving DNA passage through a cleaved DNA duplex. Here the authors present the crystal structure of the ParE ATPase domains of S. pneumoniae topoisomerase IV, in complex with a captured DNA oligonucleotide.

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