Insulin resistance is linked to a specific profile of immune activation in human subjects

Abstract We tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation profiles may b...

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Autores principales:	Renaud Cezar, Delphine Desigaud, Manuela Pastore, Lucy Kundura, Anne-Marie Dupuy, Chantal Cognot, Thierry Vincent, Christelle Reynes, Robert Sabatier, Elisabeth Maggia, Pierre Corbeau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17d11f43d3ac4fe0b67d3fe5b6818b6f
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spelling	oai:doaj.org-article:17d11f43d3ac4fe0b67d3fe5b6818b6f2021-12-02T17:30:40ZInsulin resistance is linked to a specific profile of immune activation in human subjects10.1038/s41598-021-91758-32045-2322https://doaj.org/article/17d11f43d3ac4fe0b67d3fe5b6818b6f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91758-3https://doaj.org/toc/2045-2322Abstract We tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation profiles may be distinguished in 150 volunteers. One of these profiles, Profile 2, characterized by CD4+ T cell senescence, inflammation, monocyte, B cell, and endothelial activation, presented elevated insulinemia, glycemia, triglyceridemia, and γ-glutamyl transferase, a marker of liver injury, in comparison with other profiles. Our data are compatible with a model in which a particular immune activation profile might favor the development of insulin resistance and metabolic syndrome. In this hypothesis, identification of this profile, that is feasible with only 3 markers with an error rate of 5%, might allow to personalize the screening and prevention of metabolic syndrome-driven morbidities as liver steatosis.Renaud CezarDelphine DesigaudManuela PastoreLucy KunduraAnne-Marie DupuyChantal CognotThierry VincentChristelle ReynesRobert SabatierElisabeth MaggiaPierre CorbeauNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Renaud Cezar Delphine Desigaud Manuela Pastore Lucy Kundura Anne-Marie Dupuy Chantal Cognot Thierry Vincent Christelle Reynes Robert Sabatier Elisabeth Maggia Pierre Corbeau Insulin resistance is linked to a specific profile of immune activation in human subjects
description	Abstract We tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation profiles may be distinguished in 150 volunteers. One of these profiles, Profile 2, characterized by CD4+ T cell senescence, inflammation, monocyte, B cell, and endothelial activation, presented elevated insulinemia, glycemia, triglyceridemia, and γ-glutamyl transferase, a marker of liver injury, in comparison with other profiles. Our data are compatible with a model in which a particular immune activation profile might favor the development of insulin resistance and metabolic syndrome. In this hypothesis, identification of this profile, that is feasible with only 3 markers with an error rate of 5%, might allow to personalize the screening and prevention of metabolic syndrome-driven morbidities as liver steatosis.
format	article
author	Renaud Cezar Delphine Desigaud Manuela Pastore Lucy Kundura Anne-Marie Dupuy Chantal Cognot Thierry Vincent Christelle Reynes Robert Sabatier Elisabeth Maggia Pierre Corbeau
author_facet	Renaud Cezar Delphine Desigaud Manuela Pastore Lucy Kundura Anne-Marie Dupuy Chantal Cognot Thierry Vincent Christelle Reynes Robert Sabatier Elisabeth Maggia Pierre Corbeau
author_sort	Renaud Cezar
title	Insulin resistance is linked to a specific profile of immune activation in human subjects
title_short	Insulin resistance is linked to a specific profile of immune activation in human subjects
title_full	Insulin resistance is linked to a specific profile of immune activation in human subjects
title_fullStr	Insulin resistance is linked to a specific profile of immune activation in human subjects
title_full_unstemmed	Insulin resistance is linked to a specific profile of immune activation in human subjects
title_sort	insulin resistance is linked to a specific profile of immune activation in human subjects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/17d11f43d3ac4fe0b67d3fe5b6818b6f
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Insulin resistance is linked to a specific profile of immune activation in human subjects

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