Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries

Abstract HIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-s...

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Autores principales:	Pedro M. M. Araújo, Alexandre Carvalho, Marta Pingarilho, BEST-HOPE study group, Ana B. Abecasis, Nuno S. Osório
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17d143802a594dcd86c324cc4d0ed069
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spelling	oai:doaj.org-article:17d143802a594dcd86c324cc4d0ed0692021-12-02T16:08:04ZCharacterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries10.1038/s41598-019-43420-22045-2322https://doaj.org/article/17d143802a594dcd86c324cc4d0ed0692019-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-43420-2https://doaj.org/toc/2045-2322Abstract HIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 closely related database sequences. 80% of the A1 Portuguese isolates gathered in a main phylogenetic clade (MA1). Six transmission clusters were identified in MA1, encompassing isolates from Portugal, Spain, France, and United Kingdom. The most common transmission route identified was men who have sex with men. The origin of the MA1 was linked to Greece, with the first introduction to Portugal dating back to 1996 (95% HPD: 1993.6–1999.2). Individuals infected with MA1 virus revealed lower viral loads and higher CD4+ T-cell counts in comparison with those infected by subtype B. The expanding A1 clusters in Portugal are connected to other European countries and share a recent common ancestor with the Greek A1 outbreak. The recent expansion of this HIV-1 subtype might be related to a slower disease progression leading to a population level delay in its diagnostic.Pedro M. M. AraújoAlexandre CarvalhoMarta PingarilhoBEST-HOPE study groupAna B. AbecasisNuno S. OsórioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pedro M. M. Araújo Alexandre Carvalho Marta Pingarilho BEST-HOPE study group Ana B. Abecasis Nuno S. Osório Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries
description	Abstract HIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 closely related database sequences. 80% of the A1 Portuguese isolates gathered in a main phylogenetic clade (MA1). Six transmission clusters were identified in MA1, encompassing isolates from Portugal, Spain, France, and United Kingdom. The most common transmission route identified was men who have sex with men. The origin of the MA1 was linked to Greece, with the first introduction to Portugal dating back to 1996 (95% HPD: 1993.6–1999.2). Individuals infected with MA1 virus revealed lower viral loads and higher CD4+ T-cell counts in comparison with those infected by subtype B. The expanding A1 clusters in Portugal are connected to other European countries and share a recent common ancestor with the Greek A1 outbreak. The recent expansion of this HIV-1 subtype might be related to a slower disease progression leading to a population level delay in its diagnostic.
format	article
author	Pedro M. M. Araújo Alexandre Carvalho Marta Pingarilho BEST-HOPE study group Ana B. Abecasis Nuno S. Osório
author_facet	Pedro M. M. Araújo Alexandre Carvalho Marta Pingarilho BEST-HOPE study group Ana B. Abecasis Nuno S. Osório
author_sort	Pedro M. M. Araújo
title	Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries
title_short	Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries
title_full	Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries
title_fullStr	Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries
title_full_unstemmed	Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries
title_sort	characterization of a large cluster of hiv-1 a1 infections detected in portugal and connected to several western european countries
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/17d143802a594dcd86c324cc4d0ed069
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Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries

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