Silica nanoparticle stability in biological media revisited

Abstract The stability of silica nanostructure in the core-silica shell nanomaterials is critical to understanding the activity of these nanomaterials since the exposure of core materials due to the poor stability of silica may cause misinterpretation of experiments, but unfortunately reports on the...

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Autores principales:	Seon-Ah Yang, Sungmoon Choi, Seon Mi Jeon, Junhua Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17d5376be50542ac8dfc0c4ee798d1ca
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spelling	oai:doaj.org-article:17d5376be50542ac8dfc0c4ee798d1ca2021-12-02T15:08:06ZSilica nanoparticle stability in biological media revisited10.1038/s41598-017-18502-82045-2322https://doaj.org/article/17d5376be50542ac8dfc0c4ee798d1ca2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-18502-8https://doaj.org/toc/2045-2322Abstract The stability of silica nanostructure in the core-silica shell nanomaterials is critical to understanding the activity of these nanomaterials since the exposure of core materials due to the poor stability of silica may cause misinterpretation of experiments, but unfortunately reports on the stability of silica have been inconsistent. Here, we show that luminescent silver nanodots (AgNDs) can be used to monitor the stability of silica nanostructures. Though relatively stable in water and phosphate buffered saline, silica nanoparticles are eroded by biological media, leading to the exposure of AgNDs from AgND@SiO2 nanoparticles and the quenching of nanodot luminescence. Our results reveal that a synergistic effect of organic compounds, particularly the amino groups, accelerates the erosion. Our work indicates that silica nanostructures are vulnerable to cellular medium and it may be possible to tune the release of drug molecules from silica-based drug delivery vehicles through controlled erosion.Seon-Ah YangSungmoon ChoiSeon Mi JeonJunhua YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seon-Ah Yang Sungmoon Choi Seon Mi Jeon Junhua Yu Silica nanoparticle stability in biological media revisited
description	Abstract The stability of silica nanostructure in the core-silica shell nanomaterials is critical to understanding the activity of these nanomaterials since the exposure of core materials due to the poor stability of silica may cause misinterpretation of experiments, but unfortunately reports on the stability of silica have been inconsistent. Here, we show that luminescent silver nanodots (AgNDs) can be used to monitor the stability of silica nanostructures. Though relatively stable in water and phosphate buffered saline, silica nanoparticles are eroded by biological media, leading to the exposure of AgNDs from AgND@SiO2 nanoparticles and the quenching of nanodot luminescence. Our results reveal that a synergistic effect of organic compounds, particularly the amino groups, accelerates the erosion. Our work indicates that silica nanostructures are vulnerable to cellular medium and it may be possible to tune the release of drug molecules from silica-based drug delivery vehicles through controlled erosion.
format	article
author	Seon-Ah Yang Sungmoon Choi Seon Mi Jeon Junhua Yu
author_facet	Seon-Ah Yang Sungmoon Choi Seon Mi Jeon Junhua Yu
author_sort	Seon-Ah Yang
title	Silica nanoparticle stability in biological media revisited
title_short	Silica nanoparticle stability in biological media revisited
title_full	Silica nanoparticle stability in biological media revisited
title_fullStr	Silica nanoparticle stability in biological media revisited
title_full_unstemmed	Silica nanoparticle stability in biological media revisited
title_sort	silica nanoparticle stability in biological media revisited
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/17d5376be50542ac8dfc0c4ee798d1ca
work_keys_str_mv	AT seonahyang silicananoparticlestabilityinbiologicalmediarevisited AT sungmoonchoi silicananoparticlestabilityinbiologicalmediarevisited AT seonmijeon silicananoparticlestabilityinbiologicalmediarevisited AT junhuayu silicananoparticlestabilityinbiologicalmediarevisited
_version_	1718388235551375360

Silica nanoparticle stability in biological media revisited

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