The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.

<h4>Background</h4>Yes-associated protein 1 (YAP1) is a key effector molecule regulated by the Hippo pathway and described as a poor prognostic factor in breast cancer. Tumor protein 53 (TP53) mutation is well known as a biomarker related to poor survival outcomes. So far clinical charac...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoon Jin Cha, Dooreh Kim, Soong June Bae, Sung Gwe Ahn, Joon Jeong, Min Kyung Cho, Pill Sun Paik, Tae-Kyung Yoo, Woo-Chan Park, Chang Ik Yoon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17de6630c8b04eb7ad5fe3cea0909380
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:17de6630c8b04eb7ad5fe3cea0909380
record_format	dspace
spelling	oai:doaj.org-article:17de6630c8b04eb7ad5fe3cea09093802021-12-02T20:11:25ZThe association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.1932-620310.1371/journal.pone.0250986https://doaj.org/article/17de6630c8b04eb7ad5fe3cea09093802021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0250986https://doaj.org/toc/1932-6203<h4>Background</h4>Yes-associated protein 1 (YAP1) is a key effector molecule regulated by the Hippo pathway and described as a poor prognostic factor in breast cancer. Tumor protein 53 (TP53) mutation is well known as a biomarker related to poor survival outcomes. So far clinical characteristics and survival outcome according to YAP1 and TP53 mutation have been poorly identified in breast cancer.<h4>Patients and methods</h4>Retrospectively, 533 breast tumor tissues were collected at the Seoul St Mary's hospital and Gangnam Severance Hospital from 1992 to 2017. Immunohistochemistry with YAP1 and p53 specific antibodies were performed, and the clinical data were analyzed.<h4>Results</h4>Mutant p53 pattern was associated with aggressive tumor features and advanced anatomical stage. Inferior overall survival (OS) and recurrence free survival (RFS) were related with mutant p53 pattern cases with low nuclear YAP1 expression (P = 0.0009 and P = 0.0011, respectively). Multivariate analysis showed that mutant p53 pattern was an independent prognostic marker for OS [hazard ratios (HR): 2.938, 95% confidence intervals (CIs): 1.028-8.395, P = 0.044] and RFS (HR: 1.842, 95% CIs: 1.026-3.304). However, in cases with high nuclear YAP1 expression, there were no significantly difference in OS and RFS according to p53 staining pattern.<h4>Conclusion</h4>We found that mutant p53 pattern is a poor prognostic biomarker in breast tumor with low nuclear YAP1 expression. Our findings suggest that interaction between nuclear YAP1 and p53 expression pattern impact survival outcomes.Yoon Jin ChaDooreh KimSoong June BaeSung Gwe AhnJoon JeongMin Kyung ChoPill Sun PaikTae-Kyung YooWoo-Chan ParkChang Ik YoonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0250986 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoon Jin Cha Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Min Kyung Cho Pill Sun Paik Tae-Kyung Yoo Woo-Chan Park Chang Ik Yoon The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.
description	<h4>Background</h4>Yes-associated protein 1 (YAP1) is a key effector molecule regulated by the Hippo pathway and described as a poor prognostic factor in breast cancer. Tumor protein 53 (TP53) mutation is well known as a biomarker related to poor survival outcomes. So far clinical characteristics and survival outcome according to YAP1 and TP53 mutation have been poorly identified in breast cancer.<h4>Patients and methods</h4>Retrospectively, 533 breast tumor tissues were collected at the Seoul St Mary's hospital and Gangnam Severance Hospital from 1992 to 2017. Immunohistochemistry with YAP1 and p53 specific antibodies were performed, and the clinical data were analyzed.<h4>Results</h4>Mutant p53 pattern was associated with aggressive tumor features and advanced anatomical stage. Inferior overall survival (OS) and recurrence free survival (RFS) were related with mutant p53 pattern cases with low nuclear YAP1 expression (P = 0.0009 and P = 0.0011, respectively). Multivariate analysis showed that mutant p53 pattern was an independent prognostic marker for OS [hazard ratios (HR): 2.938, 95% confidence intervals (CIs): 1.028-8.395, P = 0.044] and RFS (HR: 1.842, 95% CIs: 1.026-3.304). However, in cases with high nuclear YAP1 expression, there were no significantly difference in OS and RFS according to p53 staining pattern.<h4>Conclusion</h4>We found that mutant p53 pattern is a poor prognostic biomarker in breast tumor with low nuclear YAP1 expression. Our findings suggest that interaction between nuclear YAP1 and p53 expression pattern impact survival outcomes.
format	article
author	Yoon Jin Cha Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Min Kyung Cho Pill Sun Paik Tae-Kyung Yoo Woo-Chan Park Chang Ik Yoon
author_facet	Yoon Jin Cha Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Min Kyung Cho Pill Sun Paik Tae-Kyung Yoo Woo-Chan Park Chang Ik Yoon
author_sort	Yoon Jin Cha
title	The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.
title_short	The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.
title_full	The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.
title_fullStr	The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.
title_full_unstemmed	The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.
title_sort	association between the expression of nuclear yes-associated protein 1 (yap1) and p53 protein expression profile in breast cancer patients.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/17de6630c8b04eb7ad5fe3cea0909380
work_keys_str_mv	AT yoonjincha theassociationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT doorehkim theassociationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT soongjunebae theassociationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT sunggweahn theassociationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT joonjeong theassociationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT minkyungcho theassociationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT pillsunpaik theassociationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT taekyungyoo theassociationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT woochanpark theassociationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT changikyoon theassociationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT yoonjincha associationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT doorehkim associationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT soongjunebae associationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT sunggweahn associationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT joonjeong associationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT minkyungcho associationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT pillsunpaik associationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT taekyungyoo associationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT woochanpark associationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients AT changikyoon associationbetweentheexpressionofnuclearyesassociatedprotein1yap1andp53proteinexpressionprofileinbreastcancerpatients
_version_	1718374868877049856

The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.

Ejemplares similares