PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain

The cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels.

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Autores principales:	Maorong Wen, Yunlei Cao, Bin Wu, Taoran Xiao, Ruiyu Cao, Qian Wang, Xiwei Liu, Hongjuan Xue, Yang Yu, Jialing Lin, Chenqi Xu, Jie Xu, Bo OuYang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17e35fdce2dc46e3ae4946ce57c81587
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:17e35fdce2dc46e3ae4946ce57c815872021-12-02T19:02:36ZPD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain10.1038/s41467-021-25416-72041-1723https://doaj.org/article/17e35fdce2dc46e3ae4946ce57c815872021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25416-7https://doaj.org/toc/2041-1723The cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels.Maorong WenYunlei CaoBin WuTaoran XiaoRuiyu CaoQian WangXiwei LiuHongjuan XueYang YuJialing LinChenqi XuJie XuBo OuYangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maorong Wen Yunlei Cao Bin Wu Taoran Xiao Ruiyu Cao Qian Wang Xiwei Liu Hongjuan Xue Yang Yu Jialing Lin Chenqi Xu Jie Xu Bo OuYang PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
description	The cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels.
format	article
author	Maorong Wen Yunlei Cao Bin Wu Taoran Xiao Ruiyu Cao Qian Wang Xiwei Liu Hongjuan Xue Yang Yu Jialing Lin Chenqi Xu Jie Xu Bo OuYang
author_facet	Maorong Wen Yunlei Cao Bin Wu Taoran Xiao Ruiyu Cao Qian Wang Xiwei Liu Hongjuan Xue Yang Yu Jialing Lin Chenqi Xu Jie Xu Bo OuYang
author_sort	Maorong Wen
title	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
title_short	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
title_full	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
title_fullStr	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
title_full_unstemmed	PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
title_sort	pd-l1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/17e35fdce2dc46e3ae4946ce57c81587
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PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain

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