miRNAs Related to Different Processes of Fracture Healing: An Integrative Overview

Fracture healing is a complex, dynamic process that is directed by cellular communication and requires multiple cell types, such as osteoblasts, osteoclasts, and immune cells. Physiological fracture healing can be divided into several phases that consist of different processes, such as angiogenesis,...

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Autores principales:	Rald V. M. Groven, Johan van Koll, Martijn Poeze, Taco J. Blokhuis, Martijn van Griensven
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	miRNAs fracture healing bone regeneration osteogenic differentiation angiogenesis hypoxia Surgery RD1-811
Acceso en línea:	https://doaj.org/article/17e5d2899e044126bf3fa542fa1f1646
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spelling	oai:doaj.org-article:17e5d2899e044126bf3fa542fa1f16462021-11-19T05:00:29ZmiRNAs Related to Different Processes of Fracture Healing: An Integrative Overview2296-875X10.3389/fsurg.2021.786564https://doaj.org/article/17e5d2899e044126bf3fa542fa1f16462021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fsurg.2021.786564/fullhttps://doaj.org/toc/2296-875XFracture healing is a complex, dynamic process that is directed by cellular communication and requires multiple cell types, such as osteoblasts, osteoclasts, and immune cells. Physiological fracture healing can be divided into several phases that consist of different processes, such as angiogenesis, osteogenesis, and bone resorption/remodelling. This is needed to guarantee proper bone regeneration after fracture. Communication and molecular regulation between different cell types and within cells is therefore key in successfully orchestrating these processes to ensure adequate bone healing. Among others, microRNAs (miRNAs) play an important role in cellular communication. microRNAs are small, non-coding RNA molecules of ~22 nucleotides long that can greatly influence gene expression by post-transcriptional regulation. Over the course of the past decade, more insights have been gained in the field of miRNAs and their role in cellular signalling in both inter- and intracellular pathways. The interplay between miRNAs and their mRNA targets, and the effect thereof on different processes and aspects within fracture healing, have shown to be interesting research topics with possible future diagnostic and therapeutic potential. Considering bone regeneration, research moreover focusses on specific microRNAs and their involvement in individual pathways. However, it is required to combine these data to gain more understanding on the effects of miRNAs in the dynamic process of fracture healing, and to enhance their translational application in research, as well as in the clinic. Therefore, this review aims to provide an integrative overview on miRNAs in fracture healing, related to several key aspects in the fracture healing cascade. A special focus will be put on hypoxia, angiogenesis, bone resorption, osteoclastogenesis, mineralization, osteogenesis, osteoblastogenesis, osteocytogenesis, and chondrogenesis.Rald V. M. GrovenRald V. M. GrovenJohan van KollMartijn PoezeTaco J. BlokhuisMartijn van GriensvenFrontiers Media S.A.articlemiRNAsfracture healingbone regenerationosteogenic differentiationangiogenesishypoxiaSurgeryRD1-811ENFrontiers in Surgery, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	miRNAs fracture healing bone regeneration osteogenic differentiation angiogenesis hypoxia Surgery RD1-811
spellingShingle	miRNAs fracture healing bone regeneration osteogenic differentiation angiogenesis hypoxia Surgery RD1-811 Rald V. M. Groven Rald V. M. Groven Johan van Koll Martijn Poeze Taco J. Blokhuis Martijn van Griensven miRNAs Related to Different Processes of Fracture Healing: An Integrative Overview
description	Fracture healing is a complex, dynamic process that is directed by cellular communication and requires multiple cell types, such as osteoblasts, osteoclasts, and immune cells. Physiological fracture healing can be divided into several phases that consist of different processes, such as angiogenesis, osteogenesis, and bone resorption/remodelling. This is needed to guarantee proper bone regeneration after fracture. Communication and molecular regulation between different cell types and within cells is therefore key in successfully orchestrating these processes to ensure adequate bone healing. Among others, microRNAs (miRNAs) play an important role in cellular communication. microRNAs are small, non-coding RNA molecules of ~22 nucleotides long that can greatly influence gene expression by post-transcriptional regulation. Over the course of the past decade, more insights have been gained in the field of miRNAs and their role in cellular signalling in both inter- and intracellular pathways. The interplay between miRNAs and their mRNA targets, and the effect thereof on different processes and aspects within fracture healing, have shown to be interesting research topics with possible future diagnostic and therapeutic potential. Considering bone regeneration, research moreover focusses on specific microRNAs and their involvement in individual pathways. However, it is required to combine these data to gain more understanding on the effects of miRNAs in the dynamic process of fracture healing, and to enhance their translational application in research, as well as in the clinic. Therefore, this review aims to provide an integrative overview on miRNAs in fracture healing, related to several key aspects in the fracture healing cascade. A special focus will be put on hypoxia, angiogenesis, bone resorption, osteoclastogenesis, mineralization, osteogenesis, osteoblastogenesis, osteocytogenesis, and chondrogenesis.
format	article
author	Rald V. M. Groven Rald V. M. Groven Johan van Koll Martijn Poeze Taco J. Blokhuis Martijn van Griensven
author_facet	Rald V. M. Groven Rald V. M. Groven Johan van Koll Martijn Poeze Taco J. Blokhuis Martijn van Griensven
author_sort	Rald V. M. Groven
title	miRNAs Related to Different Processes of Fracture Healing: An Integrative Overview
title_short	miRNAs Related to Different Processes of Fracture Healing: An Integrative Overview
title_full	miRNAs Related to Different Processes of Fracture Healing: An Integrative Overview
title_fullStr	miRNAs Related to Different Processes of Fracture Healing: An Integrative Overview
title_full_unstemmed	miRNAs Related to Different Processes of Fracture Healing: An Integrative Overview
title_sort	mirnas related to different processes of fracture healing: an integrative overview
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/17e5d2899e044126bf3fa542fa1f1646
work_keys_str_mv	AT raldvmgroven mirnasrelatedtodifferentprocessesoffracturehealinganintegrativeoverview AT raldvmgroven mirnasrelatedtodifferentprocessesoffracturehealinganintegrativeoverview AT johanvankoll mirnasrelatedtodifferentprocessesoffracturehealinganintegrativeoverview AT martijnpoeze mirnasrelatedtodifferentprocessesoffracturehealinganintegrativeoverview AT tacojblokhuis mirnasrelatedtodifferentprocessesoffracturehealinganintegrativeoverview AT martijnvangriensven mirnasrelatedtodifferentprocessesoffracturehealinganintegrativeoverview
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miRNAs Related to Different Processes of Fracture Healing: An Integrative Overview

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