Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study

Abstract The diagnostic peripheral biomarkers are still lacking for the bipolar II disorder (BD-II). We used isobaric tags for relative and absolute quantification technology to identify five upregulated candidate proteins [matrix metallopeptidase 9 (MMP9), phenylalanyl-tRNA synthetase subunit beta...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sheng-Yu Lee, Tzu-Yun Wang, Ru-Band Lu, Liang-Jen Wang, Sung-Chou Li, Chi-Ying Tu, Cheng-Ho Chang, Yung-Chih Chiang, Kuo-Wang Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17e692e372d64869b3e7a9995acecbec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:17e692e372d64869b3e7a9995acecbec
record_format	dspace
spelling	oai:doaj.org-article:17e692e372d64869b3e7a9995acecbec2021-12-02T15:38:11ZIdentification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study10.1038/s41598-021-88450-x2045-2322https://doaj.org/article/17e692e372d64869b3e7a9995acecbec2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88450-xhttps://doaj.org/toc/2045-2322Abstract The diagnostic peripheral biomarkers are still lacking for the bipolar II disorder (BD-II). We used isobaric tags for relative and absolute quantification technology to identify five upregulated candidate proteins [matrix metallopeptidase 9 (MMP9), phenylalanyl-tRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin type 9 (PCSK9)] for the diagnosis of BD-II. We analysed the differences in the plasma levels of these candidate proteins between BD-II patients and controls (BD-II, n = 185; Controls, n = 186) using ELISA. To establish a diagnostic model for the prediction of BD-II, the participants were divided randomly into a training group (BD-II, n = 149; Controls, n = 150) and a testing group (BD-II, n = 36; Controls, n = 36). Significant increases were found in all five protein levels between BD-II and controls in the training group. Logistic regression was analysed to form the composite probability score of the five proteins in the training group. Receiver-operating characteristic curve analysis revealed the diagnostic validity of the probability score [area under curve (AUC) = 0.89, P < 0.001]. The composite probability score of the testing group also showed good diagnostic validity (AUC = 0.86, P < 0.001). We propose that plasma levels of PRDX2, CA-1, FARSB, MMP9, and PCSK9 may be associated with BD-II as potential biomarkers.Sheng-Yu LeeTzu-Yun WangRu-Band LuLiang-Jen WangSung-Chou LiChi-Ying TuCheng-Ho ChangYung-Chih ChiangKuo-Wang TsaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sheng-Yu Lee Tzu-Yun Wang Ru-Band Lu Liang-Jen Wang Sung-Chou Li Chi-Ying Tu Cheng-Ho Chang Yung-Chih Chiang Kuo-Wang Tsai Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study
description	Abstract The diagnostic peripheral biomarkers are still lacking for the bipolar II disorder (BD-II). We used isobaric tags for relative and absolute quantification technology to identify five upregulated candidate proteins [matrix metallopeptidase 9 (MMP9), phenylalanyl-tRNA synthetase subunit beta (FARSB), peroxiredoxin 2 (PRDX2), carbonic anhydrase 1 (CA-1), and proprotein convertase subtilisin/kexin type 9 (PCSK9)] for the diagnosis of BD-II. We analysed the differences in the plasma levels of these candidate proteins between BD-II patients and controls (BD-II, n = 185; Controls, n = 186) using ELISA. To establish a diagnostic model for the prediction of BD-II, the participants were divided randomly into a training group (BD-II, n = 149; Controls, n = 150) and a testing group (BD-II, n = 36; Controls, n = 36). Significant increases were found in all five protein levels between BD-II and controls in the training group. Logistic regression was analysed to form the composite probability score of the five proteins in the training group. Receiver-operating characteristic curve analysis revealed the diagnostic validity of the probability score [area under curve (AUC) = 0.89, P < 0.001]. The composite probability score of the testing group also showed good diagnostic validity (AUC = 0.86, P < 0.001). We propose that plasma levels of PRDX2, CA-1, FARSB, MMP9, and PCSK9 may be associated with BD-II as potential biomarkers.
format	article
author	Sheng-Yu Lee Tzu-Yun Wang Ru-Band Lu Liang-Jen Wang Sung-Chou Li Chi-Ying Tu Cheng-Ho Chang Yung-Chih Chiang Kuo-Wang Tsai
author_facet	Sheng-Yu Lee Tzu-Yun Wang Ru-Band Lu Liang-Jen Wang Sung-Chou Li Chi-Ying Tu Cheng-Ho Chang Yung-Chih Chiang Kuo-Wang Tsai
author_sort	Sheng-Yu Lee
title	Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study
title_short	Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study
title_full	Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study
title_fullStr	Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study
title_full_unstemmed	Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study
title_sort	identification of potential plasma protein biomarkers for bipolar ii disorder: a preliminary/exploratory study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/17e692e372d64869b3e7a9995acecbec
work_keys_str_mv	AT shengyulee identificationofpotentialplasmaproteinbiomarkersforbipolariidisorderapreliminaryexploratorystudy AT tzuyunwang identificationofpotentialplasmaproteinbiomarkersforbipolariidisorderapreliminaryexploratorystudy AT rubandlu identificationofpotentialplasmaproteinbiomarkersforbipolariidisorderapreliminaryexploratorystudy AT liangjenwang identificationofpotentialplasmaproteinbiomarkersforbipolariidisorderapreliminaryexploratorystudy AT sungchouli identificationofpotentialplasmaproteinbiomarkersforbipolariidisorderapreliminaryexploratorystudy AT chiyingtu identificationofpotentialplasmaproteinbiomarkersforbipolariidisorderapreliminaryexploratorystudy AT chenghochang identificationofpotentialplasmaproteinbiomarkersforbipolariidisorderapreliminaryexploratorystudy AT yungchihchiang identificationofpotentialplasmaproteinbiomarkersforbipolariidisorderapreliminaryexploratorystudy AT kuowangtsai identificationofpotentialplasmaproteinbiomarkersforbipolariidisorderapreliminaryexploratorystudy
_version_	1718386155695636480

Identification of potential plasma protein biomarkers for bipolar II disorder: a preliminary/exploratory study

Ejemplares similares