Sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.

<h4>Background</h4>The threshold-based (TB) trabeculated and papillary muscle mass (TPM) quantification method for cardiac MRI (CMR) calculates different values than conventional contouring techniques. We aimed to identify the sex- and age-related normal reference ranges for left ventric...

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Autores principales:	Zsófia Gregor, Anna Réka Kiss, Liliána Erzsébet Szabó, Attila Tóth, Kinga Grebur, Márton Horváth, Zsófia Dohy, Béla Merkely, Hajnalka Vágó, Andrea Szűcs
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17e8f31e1aee4d239871d6a6a5e61637
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spelling	oai:doaj.org-article:17e8f31e1aee4d239871d6a6a5e616372021-12-02T20:19:18ZSex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.1932-620310.1371/journal.pone.0258362https://doaj.org/article/17e8f31e1aee4d239871d6a6a5e616372021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258362https://doaj.org/toc/1932-6203<h4>Background</h4>The threshold-based (TB) trabeculated and papillary muscle mass (TPM) quantification method for cardiac MRI (CMR) calculates different values than conventional contouring techniques. We aimed to identify the sex- and age-related normal reference ranges for left ventricular (LV) myocardial mass values, volumetric and functional parameters and the correspondence of these parameters using the TB method.<h4>Methods</h4>Healthy European adults (n = 200, age: 39.4 ± 12 years, males: 100) were examined with CMR and evaluated with a TB postprocessing method. They were stratified by sex and age (Group A: 18-29, Group B: 30-39, Group C: 40-49, Group D: >50 years). The calculated parameters were indexed to body surface area (i).<h4>Results</h4>The normal reference ranges for the studied parameters were assessed in each age group. Significant biometric differences in LV parameters and mass-to-volume ratios were found between males and females, and the left ventricular compacted myocardial mass (LVCMi) and TPMi differences remained significant after stratification by age. Unlike other LV volumetric and functional parameters and mass-to-volume ratios, the TPMi, the LVCMi and the TPMi-to-LVCMi ratio did not differ among age groups in males or females. This finding was strengthened by the lack of correlation between TPMi and age.<h4>Conclusions</h4>Age- and sex-related normal reference ranges for LV volumetric and functional parameters and LVCMi and TPMi values were established using a TB postprocessing method. TPMi, LVCMi and their ratio did not change over time. The TPMi-to-LVCMi and the mass-to-volume ratios might have clinical utility in the differential diagnosis of conditions with LV hypertrabeculation.Zsófia GregorAnna Réka KissLiliána Erzsébet SzabóAttila TóthKinga GreburMárton HorváthZsófia DohyBéla MerkelyHajnalka VágóAndrea SzűcsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258362 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zsófia Gregor Anna Réka Kiss Liliána Erzsébet Szabó Attila Tóth Kinga Grebur Márton Horváth Zsófia Dohy Béla Merkely Hajnalka Vágó Andrea Szűcs Sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.
description	<h4>Background</h4>The threshold-based (TB) trabeculated and papillary muscle mass (TPM) quantification method for cardiac MRI (CMR) calculates different values than conventional contouring techniques. We aimed to identify the sex- and age-related normal reference ranges for left ventricular (LV) myocardial mass values, volumetric and functional parameters and the correspondence of these parameters using the TB method.<h4>Methods</h4>Healthy European adults (n = 200, age: 39.4 ± 12 years, males: 100) were examined with CMR and evaluated with a TB postprocessing method. They were stratified by sex and age (Group A: 18-29, Group B: 30-39, Group C: 40-49, Group D: >50 years). The calculated parameters were indexed to body surface area (i).<h4>Results</h4>The normal reference ranges for the studied parameters were assessed in each age group. Significant biometric differences in LV parameters and mass-to-volume ratios were found between males and females, and the left ventricular compacted myocardial mass (LVCMi) and TPMi differences remained significant after stratification by age. Unlike other LV volumetric and functional parameters and mass-to-volume ratios, the TPMi, the LVCMi and the TPMi-to-LVCMi ratio did not differ among age groups in males or females. This finding was strengthened by the lack of correlation between TPMi and age.<h4>Conclusions</h4>Age- and sex-related normal reference ranges for LV volumetric and functional parameters and LVCMi and TPMi values were established using a TB postprocessing method. TPMi, LVCMi and their ratio did not change over time. The TPMi-to-LVCMi and the mass-to-volume ratios might have clinical utility in the differential diagnosis of conditions with LV hypertrabeculation.
format	article
author	Zsófia Gregor Anna Réka Kiss Liliána Erzsébet Szabó Attila Tóth Kinga Grebur Márton Horváth Zsófia Dohy Béla Merkely Hajnalka Vágó Andrea Szűcs
author_facet	Zsófia Gregor Anna Réka Kiss Liliána Erzsébet Szabó Attila Tóth Kinga Grebur Márton Horváth Zsófia Dohy Béla Merkely Hajnalka Vágó Andrea Szűcs
author_sort	Zsófia Gregor
title	Sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.
title_short	Sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.
title_full	Sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.
title_fullStr	Sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.
title_full_unstemmed	Sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.
title_sort	sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/17e8f31e1aee4d239871d6a6a5e61637
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Sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.

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