Increased neutrophil–lymphocyte ratio in delirium: a pilot study

Increased neutrophil–lymphocyte ratio in delirium: a pilot study

Angelique Egberts, Francesco US Mattace-Raso Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands Aim: Delirium is a common and severe complication among older hospitalized patients. The pathophysiology is poorly understood,...

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Autores principales: Egberts A, Mattace-Raso FUS
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
delirium
pathology
biomarkers
leukocytes
immune system
brain
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/17f04ba1c82343d1b150c0ed49448922
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spelling oai:doaj.org-article:17f04ba1c82343d1b150c0ed494489222021-12-02T02:07:59ZIncreased neutrophil–lymphocyte ratio in delirium: a pilot study1178-1998https://doaj.org/article/17f04ba1c82343d1b150c0ed494489222017-07-01T00:00:00Zhttps://www.dovepress.com/increased-neutrophilndashlymphocyte-ratio-in-delirium-a-pilot-study-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Angelique Egberts, Francesco US Mattace-Raso Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands Aim: Delirium is a common and severe complication among older hospitalized patients. The pathophysiology is poorly understood, but it has been suggested that inflammation and oxidative stress may play a role. The aim of this pilot study was to investigate levels of the neutrophil–lymphocyte ratio (NLR) – a marker of systemic inflammation and oxidative stress – in patients with and without delirium. Methods: This pilot study was performed within a retrospective chart review study that included acutely ill patients, 65 years and older, who were admitted to the ward of geriatrics of the Erasmus University Medical Center. All patients in whom the differential white blood cell (WBC) counts as well as the C-reactive protein (CRP) level were determined within 24 h after admission were included in the present study. Differences in NLR between patients with and without delirium were investigated using univariate analysis of variance, with adjustments for age, sex, comorbidities, CRP level, and total WBC count. Results: Eighty-six patients were included. Thirteen patients were diagnosed with delirium. In adjusted models, higher mean NLR values were found in patients with, than in those without, delirium (9.10 vs 5.18, P=0.003). Conclusion: In this pilot study, we found increased NLR levels in patients with delirium. This finding might suggest that an inadequate response of the immune system and oxidative stress may play a role in the pathogenesis of delirium. Further studies are needed to confirm the association between NLR and delirium. Keywords: delirium, pathology, biomarkers, leukocytes, immune system, brain Egberts AMattace-Raso FUSDove Medical Pressarticledeliriumpathologybiomarkersleukocytesimmune systembrainGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1115-1121 (2017)
institution DOAJ
collection DOAJ
language EN
topic delirium
pathology
biomarkers
leukocytes
immune system
brain
Geriatrics
RC952-954.6
spellingShingle delirium
pathology
biomarkers
leukocytes
immune system
brain
Geriatrics
RC952-954.6
Egberts A
Mattace-Raso FUS
Increased neutrophil–lymphocyte ratio in delirium: a pilot study
description Angelique Egberts, Francesco US Mattace-Raso Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands Aim: Delirium is a common and severe complication among older hospitalized patients. The pathophysiology is poorly understood, but it has been suggested that inflammation and oxidative stress may play a role. The aim of this pilot study was to investigate levels of the neutrophil–lymphocyte ratio (NLR) – a marker of systemic inflammation and oxidative stress – in patients with and without delirium. Methods: This pilot study was performed within a retrospective chart review study that included acutely ill patients, 65 years and older, who were admitted to the ward of geriatrics of the Erasmus University Medical Center. All patients in whom the differential white blood cell (WBC) counts as well as the C-reactive protein (CRP) level were determined within 24 h after admission were included in the present study. Differences in NLR between patients with and without delirium were investigated using univariate analysis of variance, with adjustments for age, sex, comorbidities, CRP level, and total WBC count. Results: Eighty-six patients were included. Thirteen patients were diagnosed with delirium. In adjusted models, higher mean NLR values were found in patients with, than in those without, delirium (9.10 vs 5.18, P=0.003). Conclusion: In this pilot study, we found increased NLR levels in patients with delirium. This finding might suggest that an inadequate response of the immune system and oxidative stress may play a role in the pathogenesis of delirium. Further studies are needed to confirm the association between NLR and delirium. Keywords: delirium, pathology, biomarkers, leukocytes, immune system, brain 
format article
author Egberts A
Mattace-Raso FUS
author_facet Egberts A
Mattace-Raso FUS
author_sort Egberts A
title Increased neutrophil–lymphocyte ratio in delirium: a pilot study
title_short Increased neutrophil–lymphocyte ratio in delirium: a pilot study
title_full Increased neutrophil–lymphocyte ratio in delirium: a pilot study
title_fullStr Increased neutrophil–lymphocyte ratio in delirium: a pilot study
title_full_unstemmed Increased neutrophil–lymphocyte ratio in delirium: a pilot study
title_sort increased neutrophil–lymphocyte ratio in delirium: a pilot study
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/17f04ba1c82343d1b150c0ed49448922
work_keys_str_mv AT egbertsa increasedneutrophilndashlymphocyteratioindeliriumapilotstudy
AT mattacerasofus increasedneutrophilndashlymphocyteratioindeliriumapilotstudy
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