Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice

Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice

CRISPR-Cas9 is a gene editing tool that can be used to modulate gene expression. Here, the authors report the generation of a mouse model that express all components of the CRISPR-Cas9 guide directed Synergistic Activation Mediator (SAM), demonstrate that gene activation can be achieved with various...

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Auteurs principaux: Charleen Hunt, Suzanne A. Hartford, Derek White, Evangelos Pefanis, Timothy Hanna, Clarissa Herman, Jarrell Wiley, Heather Brown, Qi Su, Yurong Xin, Dennis Voronin, Hien Nguyen, Judith Altarejos, Keith Crosby, Jeffery Haines, Sarah Cancelarich, Meghan Drummond, Sven Moller-Tank, Ryan Malpass, Jacqueline Buckley, Maria del Pilar Molina-Portela, Gustavo Droguett, David Frendewey, Eric Chiao, Brian Zambrowicz, Guochun Gong
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
Q
Accès en ligne:https://doaj.org/article/17fb14b41cbb4fa7890fbff2faf8ff19
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Résumé:CRISPR-Cas9 is a gene editing tool that can be used to modulate gene expression. Here, the authors report the generation of a mouse model that express all components of the CRISPR-Cas9 guide directed Synergistic Activation Mediator (SAM), demonstrate that gene activation can be achieved with various delivery methods and include generation of a disease model of hypercholesterolemia

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