Pathway engineering in yeast for synthesizing the complex polyketide bikaverin
Bikaverin is a fungal-derived tetracyclic polyketide with antibiotic, antifungal and anticancer properties. Here, the authors employ various pathway engineering strategies to achieve high level production of bikaverin in baker’s yeast.
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Main Authors: | Meng Zhao, Yu Zhao, Mingdong Yao, Hala Iqbal, Qi Hu, Hong Liu, Bin Qiao, Chun Li, Christine A. S. Skovbjerg, Jens Christian Nielsen, Jens Nielsen, Rasmus J. N. Frandsen, Yingjin Yuan, Jef D. Boeke |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
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Online Access: | https://doaj.org/article/17ffb0d3b9194b9cba9476bf3dd6a6d7 |
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