Neuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury

Abstract Following traumatic brain injury (TBI), ischemia and hypoxia play a major role in further worsening of the damage, a process referred to as ‘secondary injury’. Protecting neurons from causative factors of secondary injury has been the guiding principle of modern TBI management. Stimulation...

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Autores principales:	Amrit Chiluwal, Raj K. Narayan, Wayne Chaung, Neal Mehan, Ping Wang, Chad E. Bouton, Eugene V. Golanov, Chunyan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/180202d4e611486fbaace3401708679b
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spelling	oai:doaj.org-article:180202d4e611486fbaace3401708679b2021-12-02T11:40:13ZNeuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury10.1038/s41598-017-07219-32045-2322https://doaj.org/article/180202d4e611486fbaace3401708679b2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07219-3https://doaj.org/toc/2045-2322Abstract Following traumatic brain injury (TBI), ischemia and hypoxia play a major role in further worsening of the damage, a process referred to as ‘secondary injury’. Protecting neurons from causative factors of secondary injury has been the guiding principle of modern TBI management. Stimulation of trigeminal nerve induces pressor response and improves cerebral blood flow (CBF) by activating the rostral ventrolateral medulla. Moreover, it causes cerebrovasodilation through the trigemino-cerebrovascular system and trigemino-parasympathetic reflex. These effects are capable of increasing cerebral perfusion, making trigeminal nerve stimulation (TNS) a promising strategy for TBI management. Here, we investigated the use of electrical TNS for improving CBF and brain oxygen tension (PbrO2), with the goal of decreasing secondary injury. Severe TBI was produced using controlled cortical impact (CCI) in a rat model, and TNS treatment was delivered for the first hour after CCI. In comparison to TBI group, TBI animals with TNS treatment demonstrated significantly increased systemic blood pressure, CBF and PbrO2 at the hyperacute phase of TBI. Furthermore, rats in TNS-treatment group showed significantly reduced brain edema, blood-brain barrier disruption, lesion volume, and brain cortical levels of TNF-α and IL-6. These data provide strong early evidence that TNS could be an effective neuroprotective strategy.Amrit ChiluwalRaj K. NarayanWayne ChaungNeal MehanPing WangChad E. BoutonEugene V. GolanovChunyan LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amrit Chiluwal Raj K. Narayan Wayne Chaung Neal Mehan Ping Wang Chad E. Bouton Eugene V. Golanov Chunyan Li Neuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury
description	Abstract Following traumatic brain injury (TBI), ischemia and hypoxia play a major role in further worsening of the damage, a process referred to as ‘secondary injury’. Protecting neurons from causative factors of secondary injury has been the guiding principle of modern TBI management. Stimulation of trigeminal nerve induces pressor response and improves cerebral blood flow (CBF) by activating the rostral ventrolateral medulla. Moreover, it causes cerebrovasodilation through the trigemino-cerebrovascular system and trigemino-parasympathetic reflex. These effects are capable of increasing cerebral perfusion, making trigeminal nerve stimulation (TNS) a promising strategy for TBI management. Here, we investigated the use of electrical TNS for improving CBF and brain oxygen tension (PbrO2), with the goal of decreasing secondary injury. Severe TBI was produced using controlled cortical impact (CCI) in a rat model, and TNS treatment was delivered for the first hour after CCI. In comparison to TBI group, TBI animals with TNS treatment demonstrated significantly increased systemic blood pressure, CBF and PbrO2 at the hyperacute phase of TBI. Furthermore, rats in TNS-treatment group showed significantly reduced brain edema, blood-brain barrier disruption, lesion volume, and brain cortical levels of TNF-α and IL-6. These data provide strong early evidence that TNS could be an effective neuroprotective strategy.
format	article
author	Amrit Chiluwal Raj K. Narayan Wayne Chaung Neal Mehan Ping Wang Chad E. Bouton Eugene V. Golanov Chunyan Li
author_facet	Amrit Chiluwal Raj K. Narayan Wayne Chaung Neal Mehan Ping Wang Chad E. Bouton Eugene V. Golanov Chunyan Li
author_sort	Amrit Chiluwal
title	Neuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury
title_short	Neuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury
title_full	Neuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury
title_fullStr	Neuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury
title_full_unstemmed	Neuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury
title_sort	neuroprotective effects of trigeminal nerve stimulation in severe traumatic brain injury
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/180202d4e611486fbaace3401708679b
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Neuroprotective Effects of Trigeminal Nerve Stimulation in Severe Traumatic Brain Injury

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