The effect of decongestion on nasal airway patency and airflow

Abstract Nasal decongestant reduces blood flow to the nasal turbinates, reducing tissue volume and increasing nasal airway patency. This study maps the changes in nasal anatomy and measures how these changes affect nasal resistance, flow partitioning between superior and inferior cavity, flow patter...

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Autores principales:	Qiwei Xiao, Alister J. Bates, Raul Cetto, Denis J. Doorly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/180273fc95834dc68335a777525ca31f
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spelling	oai:doaj.org-article:180273fc95834dc68335a777525ca31f2021-12-02T15:33:00ZThe effect of decongestion on nasal airway patency and airflow10.1038/s41598-021-93769-62045-2322https://doaj.org/article/180273fc95834dc68335a777525ca31f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93769-6https://doaj.org/toc/2045-2322Abstract Nasal decongestant reduces blood flow to the nasal turbinates, reducing tissue volume and increasing nasal airway patency. This study maps the changes in nasal anatomy and measures how these changes affect nasal resistance, flow partitioning between superior and inferior cavity, flow patterns and wall shear stress. High-resolution MRI was applied to capture nasal anatomy in 10 healthy subjects before and after application of a topical decongestant. Computational fluid dynamics simulated nasal airflow at steady inspiratory flow rates of 15 L.min $$^{-1}$$ - 1 and 30 L.min $$^{-1}$$ - 1 . The results show decongestion mainly increases the cross-sectional area in the turbinate region and SAVR is reduced (median approximately 40 $$\%$$ % reduction) in middle and lower parts of the cavity. Decongestion reduces nasal resistance by 50 $$\%$$ % on average, while in the posterior cavity, nasal resistance decreases by a median factor of approximately 3 after decongestion. We also find decongestant regularises nasal airflow and alters the partitioning of flow, significantly decreasing flow through the superior portions of the nasal cavity. By comparing nasal anatomies and airflow in their normal state with that when pharmacologically decongested, this study provides data for a broad range of anatomy and airflow conditions, which may help characterize the extent of nasal variability.Qiwei XiaoAlister J. BatesRaul CettoDenis J. DoorlyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiwei Xiao Alister J. Bates Raul Cetto Denis J. Doorly The effect of decongestion on nasal airway patency and airflow
description	Abstract Nasal decongestant reduces blood flow to the nasal turbinates, reducing tissue volume and increasing nasal airway patency. This study maps the changes in nasal anatomy and measures how these changes affect nasal resistance, flow partitioning between superior and inferior cavity, flow patterns and wall shear stress. High-resolution MRI was applied to capture nasal anatomy in 10 healthy subjects before and after application of a topical decongestant. Computational fluid dynamics simulated nasal airflow at steady inspiratory flow rates of 15 L.min $$^{-1}$$ - 1 and 30 L.min $$^{-1}$$ - 1 . The results show decongestion mainly increases the cross-sectional area in the turbinate region and SAVR is reduced (median approximately 40 $$\%$$ % reduction) in middle and lower parts of the cavity. Decongestion reduces nasal resistance by 50 $$\%$$ % on average, while in the posterior cavity, nasal resistance decreases by a median factor of approximately 3 after decongestion. We also find decongestant regularises nasal airflow and alters the partitioning of flow, significantly decreasing flow through the superior portions of the nasal cavity. By comparing nasal anatomies and airflow in their normal state with that when pharmacologically decongested, this study provides data for a broad range of anatomy and airflow conditions, which may help characterize the extent of nasal variability.
format	article
author	Qiwei Xiao Alister J. Bates Raul Cetto Denis J. Doorly
author_facet	Qiwei Xiao Alister J. Bates Raul Cetto Denis J. Doorly
author_sort	Qiwei Xiao
title	The effect of decongestion on nasal airway patency and airflow
title_short	The effect of decongestion on nasal airway patency and airflow
title_full	The effect of decongestion on nasal airway patency and airflow
title_fullStr	The effect of decongestion on nasal airway patency and airflow
title_full_unstemmed	The effect of decongestion on nasal airway patency and airflow
title_sort	effect of decongestion on nasal airway patency and airflow
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/180273fc95834dc68335a777525ca31f
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The effect of decongestion on nasal airway patency and airflow

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