Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics

Sepsis can lead to multiple organ failure that could potentially be reflected by change in plasma protein abundance. Here the authors describe a proteomics strategy that allows the determination of plasma proteins tissue origin in a quantitative manner for use as biomarkers—illustrated in a mouse mo...

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Autores principales: Erik Malmström, Ola Kilsgård, Simon Hauri, Emanuel Smeds, Heiko Herwald, Lars Malmström, Johan Malmström
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/180515b4471648a094ca8757685ed496
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Sumario:Sepsis can lead to multiple organ failure that could potentially be reflected by change in plasma protein abundance. Here the authors describe a proteomics strategy that allows the determination of plasma proteins tissue origin in a quantitative manner for use as biomarkers—illustrated in a mouse model of sepsis.