Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: A case-control study

Background: Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) are two deadly diseases caused by the complex interaction of multiple genetic loci, lifestyle and environmental factors. Genome-wide association studies described hundreds of susceptibility loci for T2DM and T2DM-related CV...

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Autores principales:	Tutun Das Aka, Urmi Saha, Sayara Akter Shati, Md. Abdul Aziz, Mobashera Begum, Md. Saddam Hussain, Md. Shalahuddin Millat, Mohammad Sarowar Uddin, Mohammad Safiqul Islam
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Type 2 diabetes mellitus Cardiovascular disease KCNJ11 HHEX SLC30A8 Polymorphism Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/1805a46495ef4b80b988efeb11fe619f
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spelling	oai:doaj.org-article:1805a46495ef4b80b988efeb11fe619f2021-12-02T05:02:55ZRisk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: A case-control study2405-844010.1016/j.heliyon.2021.e08376https://doaj.org/article/1805a46495ef4b80b988efeb11fe619f2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024798https://doaj.org/toc/2405-8440Background: Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) are two deadly diseases caused by the complex interaction of multiple genetic loci, lifestyle and environmental factors. Genome-wide association studies described hundreds of susceptibility loci for T2DM and T2DM-related CVD, but it remains uncertain due to geographic and ethnic variations. The objective of this study was to evaluate the associations of KCNJ11 rs5219, SLC30A8 rs13266634 and HHEX rs1111875 polymorphisms with T2DM and related CVD. Methods: Genotyping of all three polymorphisms was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method on 250 T2DM cases and 246 healthy controls. Both descriptive and inferential statistical methods were applied using MedCalc and IBM SPSS software programs for statistical analyses. Results: A significantly increased association of KCNJ11 rs5219 (p<0.05) with T2DM was found in dominant, recessive, heterozygote, homozygote, and allele model (aOR = 2.23, 2.03, 1.90, 3.09, and 1.80, respectively). For SLC30A8 rs13266634, only dominant, heterozygote, and allele model (aOR = 3.37, 3.59, and 1.79, respectively) showed significantly increased association with T2DM. SNP rs1111875 (HHEX) also revealed 2.08, 4.18, 5.93, and 2.08-times significant association in dominant, recessive, homozygote, and allele models. Besides, a significantly reduced correlation of KCNJ11 rs5219 was found with T2DM-related CVD in the recessive and allele model (aOR = 0.40 and 0.65, respectively). Again, a significant difference was observed between T2DM-related CVD and non-CVD patients in terms of gender distribution, fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), and triglycerides (TG). Conclusions: Our investigation indicates that KCNJ11 rs5219, SLC30A8 rs13266634 and HHEX rs1111875 polymorphisms are associated with T2DM. Moreover, KCNJ11 rs5219 polymorphism is correlated with the risk of T2DM-related CVD.Tutun Das AkaUrmi SahaSayara Akter ShatiMd. Abdul AzizMobashera BegumMd. Saddam HussainMd. Shalahuddin MillatMohammad Sarowar UddinMohammad Safiqul IslamElsevierarticleType 2 diabetes mellitusCardiovascular diseaseKCNJ11HHEXSLC30A8PolymorphismScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08376- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Type 2 diabetes mellitus Cardiovascular disease KCNJ11 HHEX SLC30A8 Polymorphism Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Type 2 diabetes mellitus Cardiovascular disease KCNJ11 HHEX SLC30A8 Polymorphism Science (General) Q1-390 Social sciences (General) H1-99 Tutun Das Aka Urmi Saha Sayara Akter Shati Md. Abdul Aziz Mobashera Begum Md. Saddam Hussain Md. Shalahuddin Millat Mohammad Sarowar Uddin Mohammad Safiqul Islam Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: A case-control study
description	Background: Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) are two deadly diseases caused by the complex interaction of multiple genetic loci, lifestyle and environmental factors. Genome-wide association studies described hundreds of susceptibility loci for T2DM and T2DM-related CVD, but it remains uncertain due to geographic and ethnic variations. The objective of this study was to evaluate the associations of KCNJ11 rs5219, SLC30A8 rs13266634 and HHEX rs1111875 polymorphisms with T2DM and related CVD. Methods: Genotyping of all three polymorphisms was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method on 250 T2DM cases and 246 healthy controls. Both descriptive and inferential statistical methods were applied using MedCalc and IBM SPSS software programs for statistical analyses. Results: A significantly increased association of KCNJ11 rs5219 (p<0.05) with T2DM was found in dominant, recessive, heterozygote, homozygote, and allele model (aOR = 2.23, 2.03, 1.90, 3.09, and 1.80, respectively). For SLC30A8 rs13266634, only dominant, heterozygote, and allele model (aOR = 3.37, 3.59, and 1.79, respectively) showed significantly increased association with T2DM. SNP rs1111875 (HHEX) also revealed 2.08, 4.18, 5.93, and 2.08-times significant association in dominant, recessive, homozygote, and allele models. Besides, a significantly reduced correlation of KCNJ11 rs5219 was found with T2DM-related CVD in the recessive and allele model (aOR = 0.40 and 0.65, respectively). Again, a significant difference was observed between T2DM-related CVD and non-CVD patients in terms of gender distribution, fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), and triglycerides (TG). Conclusions: Our investigation indicates that KCNJ11 rs5219, SLC30A8 rs13266634 and HHEX rs1111875 polymorphisms are associated with T2DM. Moreover, KCNJ11 rs5219 polymorphism is correlated with the risk of T2DM-related CVD.
format	article
author	Tutun Das Aka Urmi Saha Sayara Akter Shati Md. Abdul Aziz Mobashera Begum Md. Saddam Hussain Md. Shalahuddin Millat Mohammad Sarowar Uddin Mohammad Safiqul Islam
author_facet	Tutun Das Aka Urmi Saha Sayara Akter Shati Md. Abdul Aziz Mobashera Begum Md. Saddam Hussain Md. Shalahuddin Millat Mohammad Sarowar Uddin Mohammad Safiqul Islam
author_sort	Tutun Das Aka
title	Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: A case-control study
title_short	Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: A case-control study
title_full	Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: A case-control study
title_fullStr	Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: A case-control study
title_full_unstemmed	Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: A case-control study
title_sort	risk of type 2 diabetes mellitus and cardiovascular complications in kcnj11, hhex and slc30a8 genetic polymorphisms carriers: a case-control study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1805a46495ef4b80b988efeb11fe619f
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Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: A case-control study

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