Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.

In this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. We combine experimental and simulation results to establish the conditions unde...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gabriel Piedrafita, Kepa Ruiz-Mirazo, Pierre-Alain Monnard, Athel Cornish-Bowden, Francisco Montero
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1807a6ea0523406eae6edf68de8fa0ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1807a6ea0523406eae6edf68de8fa0ba
record_format	dspace
spelling	oai:doaj.org-article:1807a6ea0523406eae6edf68de8fa0ba2021-11-18T07:14:15ZViability conditions for a compartmentalized protometabolic system: a semi-empirical approach.1932-620310.1371/journal.pone.0039480https://doaj.org/article/1807a6ea0523406eae6edf68de8fa0ba2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22761803/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203In this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. We combine experimental and simulation results to establish the conditions under which a reaction network with a catalytically closed organization (more specifically, an (M,R-system) would overcome the potential problem of self-suffocation that arises from the limited accessibility of nutrients to its internal reaction domain. The relationship between the permeability of the membrane, the lifetime of the key catalysts and their efficiency (reaction rate enhancement) turns out to be critical. In particular, we show how permeability values constrain the characteristic time scale of the bounded protometabolic processes. From this concrete and illustrative example we finally extend the discussion to a wider evolutionary context.Gabriel PiedrafitaKepa Ruiz-MirazoPierre-Alain MonnardAthel Cornish-BowdenFrancisco MonteroPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39480 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gabriel Piedrafita Kepa Ruiz-Mirazo Pierre-Alain Monnard Athel Cornish-Bowden Francisco Montero Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.
description	In this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. We combine experimental and simulation results to establish the conditions under which a reaction network with a catalytically closed organization (more specifically, an (M,R-system) would overcome the potential problem of self-suffocation that arises from the limited accessibility of nutrients to its internal reaction domain. The relationship between the permeability of the membrane, the lifetime of the key catalysts and their efficiency (reaction rate enhancement) turns out to be critical. In particular, we show how permeability values constrain the characteristic time scale of the bounded protometabolic processes. From this concrete and illustrative example we finally extend the discussion to a wider evolutionary context.
format	article
author	Gabriel Piedrafita Kepa Ruiz-Mirazo Pierre-Alain Monnard Athel Cornish-Bowden Francisco Montero
author_facet	Gabriel Piedrafita Kepa Ruiz-Mirazo Pierre-Alain Monnard Athel Cornish-Bowden Francisco Montero
author_sort	Gabriel Piedrafita
title	Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.
title_short	Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.
title_full	Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.
title_fullStr	Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.
title_full_unstemmed	Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.
title_sort	viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1807a6ea0523406eae6edf68de8fa0ba
work_keys_str_mv	AT gabrielpiedrafita viabilityconditionsforacompartmentalizedprotometabolicsystemasemiempiricalapproach AT keparuizmirazo viabilityconditionsforacompartmentalizedprotometabolicsystemasemiempiricalapproach AT pierrealainmonnard viabilityconditionsforacompartmentalizedprotometabolicsystemasemiempiricalapproach AT athelcornishbowden viabilityconditionsforacompartmentalizedprotometabolicsystemasemiempiricalapproach AT franciscomontero viabilityconditionsforacompartmentalizedprotometabolicsystemasemiempiricalapproach
_version_	1718423711387746304

Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.

Ejemplares similares