Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy.
<h4>Background</h4>PPARγ and RBP4 are known to regulate lipid and glucose metabolism and insulin resistance. The influences of PPARγ (C1431T and Pro12Ala) and RBP4 (-803GA) polymorphisms on metabolic syndrome in HIV-infected patients receiving anti-retroviral therapy were examined in thi...
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oai:doaj.org-article:180867dbe160408c90dbc1221019f9302021-11-18T08:09:34ZEffects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy.1932-620310.1371/journal.pone.0049102https://doaj.org/article/180867dbe160408c90dbc1221019f9302012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145084/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>PPARγ and RBP4 are known to regulate lipid and glucose metabolism and insulin resistance. The influences of PPARγ (C1431T and Pro12Ala) and RBP4 (-803GA) polymorphisms on metabolic syndrome in HIV-infected patients receiving anti-retroviral therapy were examined in this study.<h4>Materials and methods</h4>A cross-sectional study of HIV-1 infected adults with antiretroviral therapy for more than one year in the National Cheng Kung University Hospital was conducted. The gene polymorphisms were determined by quantitative PCR.<h4>Results</h4>Ninety-one patients were included in the study. Eighty-two (90.1%) patients were males with a mean age of 44.4 years. For the C1431T polymorphism in PPARγ, while patients with the T allele (48.4%) had trends toward lower rate of hypertriglyceridemia, the borderline significance together with insignificant power did not support the protective effect of the T allele against development of hypertriglyceridemia. For the Pro12Ala polymorphism in PPARγ, although patients with the Pro/Ala genotype (8.8%) had a higher level of serum LDL (138.0 vs. 111.5 mg/dl, P = 0.04) and trends toward higher rates of hypercholesterolemia and serum LDL>110 mg/dl, these variables were found to be independent of the Pro/Ala genotype in the multivariate analysis. For the -803GA polymorphism in RBP4, patients with the A allele (23.1%) more often had insulin resistance (HOMA>3.8; 33.3 vs. 8.7%, P = 0.01) and more often received anti-hypoglycemic drugs (14.3 vs. 1.4%, P = 0.04). The detrimental effect of the A allele in RBP4 -803GA polymorphism on development of insulin resistance was supported by the multivariate analysis adjusting for covariates.<h4>Conclusion</h4>The impacts of PPARγ C1431T and Pro12Ala polymorphisms on metabolism in HIV-infected patients are not significant. RBP4 -803GA polymorphism has increased risk of insulin resistance in HIV-infected patients with anti-retroviral therapy.Yuan-Pin HungNan-Yao LeeSheng-Hsiang LinHo-Ching ChangChi-Jung WuChia-Ming ChangPo-Lin ChenHsiao-Ju LinYi-Hui WuPei-Jane TsaiYau-Sheng TsaiWen-Chien KoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49102 (2012) |
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Medicine R Science Q |
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Medicine R Science Q Yuan-Pin Hung Nan-Yao Lee Sheng-Hsiang Lin Ho-Ching Chang Chi-Jung Wu Chia-Ming Chang Po-Lin Chen Hsiao-Ju Lin Yi-Hui Wu Pei-Jane Tsai Yau-Sheng Tsai Wen-Chien Ko Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy. |
| description |
<h4>Background</h4>PPARγ and RBP4 are known to regulate lipid and glucose metabolism and insulin resistance. The influences of PPARγ (C1431T and Pro12Ala) and RBP4 (-803GA) polymorphisms on metabolic syndrome in HIV-infected patients receiving anti-retroviral therapy were examined in this study.<h4>Materials and methods</h4>A cross-sectional study of HIV-1 infected adults with antiretroviral therapy for more than one year in the National Cheng Kung University Hospital was conducted. The gene polymorphisms were determined by quantitative PCR.<h4>Results</h4>Ninety-one patients were included in the study. Eighty-two (90.1%) patients were males with a mean age of 44.4 years. For the C1431T polymorphism in PPARγ, while patients with the T allele (48.4%) had trends toward lower rate of hypertriglyceridemia, the borderline significance together with insignificant power did not support the protective effect of the T allele against development of hypertriglyceridemia. For the Pro12Ala polymorphism in PPARγ, although patients with the Pro/Ala genotype (8.8%) had a higher level of serum LDL (138.0 vs. 111.5 mg/dl, P = 0.04) and trends toward higher rates of hypercholesterolemia and serum LDL>110 mg/dl, these variables were found to be independent of the Pro/Ala genotype in the multivariate analysis. For the -803GA polymorphism in RBP4, patients with the A allele (23.1%) more often had insulin resistance (HOMA>3.8; 33.3 vs. 8.7%, P = 0.01) and more often received anti-hypoglycemic drugs (14.3 vs. 1.4%, P = 0.04). The detrimental effect of the A allele in RBP4 -803GA polymorphism on development of insulin resistance was supported by the multivariate analysis adjusting for covariates.<h4>Conclusion</h4>The impacts of PPARγ C1431T and Pro12Ala polymorphisms on metabolism in HIV-infected patients are not significant. RBP4 -803GA polymorphism has increased risk of insulin resistance in HIV-infected patients with anti-retroviral therapy. |
| format |
article |
| author |
Yuan-Pin Hung Nan-Yao Lee Sheng-Hsiang Lin Ho-Ching Chang Chi-Jung Wu Chia-Ming Chang Po-Lin Chen Hsiao-Ju Lin Yi-Hui Wu Pei-Jane Tsai Yau-Sheng Tsai Wen-Chien Ko |
| author_facet |
Yuan-Pin Hung Nan-Yao Lee Sheng-Hsiang Lin Ho-Ching Chang Chi-Jung Wu Chia-Ming Chang Po-Lin Chen Hsiao-Ju Lin Yi-Hui Wu Pei-Jane Tsai Yau-Sheng Tsai Wen-Chien Ko |
| author_sort |
Yuan-Pin Hung |
| title |
Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy. |
| title_short |
Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy. |
| title_full |
Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy. |
| title_fullStr |
Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy. |
| title_full_unstemmed |
Effects of PPARγ and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy. |
| title_sort |
effects of pparγ and rbp4 gene variants on metabolic syndrome in hiv-infected patients with anti-retroviral therapy. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/180867dbe160408c90dbc1221019f930 |
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