Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys

Abstract Central poststroke pain (CPSP) develops after a stroke around the somatosensory pathway. CPSP is hypothesized to be caused by maladaptive reorganization between various brain regions. The treatment for CPSP has not been established; however, repetitive transcranial magnetic stimulation (rTM...

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Autores principales: Yoshinori Kadono, Keigo Koguchi, Ken-ichi Okada, Koichi Hosomi, Motoki Hiraishi, Takashi Ueguchi, Ikuhiro Kida, Adnan Shah, Guoxiang Liu, Youichi Saitoh
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/180bae92094a4b86881262a4c95591e2
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spelling oai:doaj.org-article:180bae92094a4b86881262a4c95591e22021-12-02T13:17:49ZRepetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys10.1038/s41598-021-85409-w2045-2322https://doaj.org/article/180bae92094a4b86881262a4c95591e22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85409-whttps://doaj.org/toc/2045-2322Abstract Central poststroke pain (CPSP) develops after a stroke around the somatosensory pathway. CPSP is hypothesized to be caused by maladaptive reorganization between various brain regions. The treatment for CPSP has not been established; however, repetitive transcranial magnetic stimulation (rTMS) to the primary motor cortex has a clinical effect. To verify the functional reorganization hypothesis for CPSP development and rTMS therapeutic mechanism, we longitudinally pursued the structural and functional changes of the brain by using two male CPSP model monkeys (Macaca fuscata) developed by unilateral hemorrhage in the ventral posterolateral nucleus of the thalamus. Application of rTMS to the ipsilesional primary motor cortex relieved the induced pain of the model monkeys. A tractography analysis revealed a decrease in the structural connectivity in the ipsilesional thalamocortical tract, and rTMS had no effect on the structural connectivity. A region of interest analysis using resting-state functional magnetic resonance imaging revealed inappropriately strengthened functional connectivity between the ipsilesional mediodorsal nucleus of the thalamus and the amygdala, which are regions associated with emotion and memory, suggesting that this may be the cause of CPSP development. Moreover, rTMS normalizes this strengthened connectivity, which may be a possible therapeutic mechanism of rTMS for CPSP.Yoshinori KadonoKeigo KoguchiKen-ichi OkadaKoichi HosomiMotoki HiraishiTakashi UeguchiIkuhiro KidaAdnan ShahGuoxiang LiuYouichi SaitohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yoshinori Kadono
Keigo Koguchi
Ken-ichi Okada
Koichi Hosomi
Motoki Hiraishi
Takashi Ueguchi
Ikuhiro Kida
Adnan Shah
Guoxiang Liu
Youichi Saitoh
Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys
description Abstract Central poststroke pain (CPSP) develops after a stroke around the somatosensory pathway. CPSP is hypothesized to be caused by maladaptive reorganization between various brain regions. The treatment for CPSP has not been established; however, repetitive transcranial magnetic stimulation (rTMS) to the primary motor cortex has a clinical effect. To verify the functional reorganization hypothesis for CPSP development and rTMS therapeutic mechanism, we longitudinally pursued the structural and functional changes of the brain by using two male CPSP model monkeys (Macaca fuscata) developed by unilateral hemorrhage in the ventral posterolateral nucleus of the thalamus. Application of rTMS to the ipsilesional primary motor cortex relieved the induced pain of the model monkeys. A tractography analysis revealed a decrease in the structural connectivity in the ipsilesional thalamocortical tract, and rTMS had no effect on the structural connectivity. A region of interest analysis using resting-state functional magnetic resonance imaging revealed inappropriately strengthened functional connectivity between the ipsilesional mediodorsal nucleus of the thalamus and the amygdala, which are regions associated with emotion and memory, suggesting that this may be the cause of CPSP development. Moreover, rTMS normalizes this strengthened connectivity, which may be a possible therapeutic mechanism of rTMS for CPSP.
format article
author Yoshinori Kadono
Keigo Koguchi
Ken-ichi Okada
Koichi Hosomi
Motoki Hiraishi
Takashi Ueguchi
Ikuhiro Kida
Adnan Shah
Guoxiang Liu
Youichi Saitoh
author_facet Yoshinori Kadono
Keigo Koguchi
Ken-ichi Okada
Koichi Hosomi
Motoki Hiraishi
Takashi Ueguchi
Ikuhiro Kida
Adnan Shah
Guoxiang Liu
Youichi Saitoh
author_sort Yoshinori Kadono
title Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys
title_short Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys
title_full Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys
title_fullStr Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys
title_full_unstemmed Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys
title_sort repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/180bae92094a4b86881262a4c95591e2
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