Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells

Abstract Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into fatty acid and sphingosine. This reaction lowers intracellular ceramide levels and concomitantly generates sphingosine used for sphingosine-1-phosphate (S1P) production. Since increases in...

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Autores principales: Michele Lai, Natalia Realini, Marco La Ferla, Ilaria Passalacqua, Giulia Matteoli, Anand Ganesan, Mauro Pistello, Chiara Maria Mazzanti, Daniele Piomelli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/180c41426d6d457d925b68d89b55c644
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