Genetic contribution to ‘theory of mind’ in adolescence

Abstract Difficulties in ‘theory of mind’ (the ability to attribute mental states to oneself or others, and to make predictions about another’s behaviour based on these attributions) have been observed in several psychiatric conditions. We investigate the genetic architecture of theory of mind in 4,...

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Autores principales:	Varun Warrier, Simon Baron-Cohen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/180e8d4ea1dc4c2b9ced2ff46ae71a4c
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spelling	oai:doaj.org-article:180e8d4ea1dc4c2b9ced2ff46ae71a4c2021-12-02T12:33:00ZGenetic contribution to ‘theory of mind’ in adolescence10.1038/s41598-018-21737-82045-2322https://doaj.org/article/180e8d4ea1dc4c2b9ced2ff46ae71a4c2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21737-8https://doaj.org/toc/2045-2322Abstract Difficulties in ‘theory of mind’ (the ability to attribute mental states to oneself or others, and to make predictions about another’s behaviour based on these attributions) have been observed in several psychiatric conditions. We investigate the genetic architecture of theory of mind in 4,577 13-year-olds who completed the Emotional Triangles Task (Triangles Task), a first-order test of theory of mind. We observe a small but significant female-advantage on the Triangles Task (Cohen’s d = 0.19, P < 0.01), in keeping with previous work using other tests of theory of mind. Genome-wide association analyses did not identify any significant loci, and SNP heritability was non-significant. Polygenic scores for six psychiatric conditions (ADHD, anorexia, autism, bipolar disorder, depression, and schizophrenia), and empathy were not associated with scores on the Triangles Task. However, polygenic scores of cognitive aptitude, and cognitive empathy, a term synonymous with theory of mind and measured using the “Reading the Mind in the Eyes” Test, were significantly associated with scores on the Triangles Task at multiple P-value thresholds, suggesting shared genetics between different measures of theory of mind and cognition.Varun WarrierSimon Baron-CohenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Varun Warrier Simon Baron-Cohen Genetic contribution to ‘theory of mind’ in adolescence
description	Abstract Difficulties in ‘theory of mind’ (the ability to attribute mental states to oneself or others, and to make predictions about another’s behaviour based on these attributions) have been observed in several psychiatric conditions. We investigate the genetic architecture of theory of mind in 4,577 13-year-olds who completed the Emotional Triangles Task (Triangles Task), a first-order test of theory of mind. We observe a small but significant female-advantage on the Triangles Task (Cohen’s d = 0.19, P < 0.01), in keeping with previous work using other tests of theory of mind. Genome-wide association analyses did not identify any significant loci, and SNP heritability was non-significant. Polygenic scores for six psychiatric conditions (ADHD, anorexia, autism, bipolar disorder, depression, and schizophrenia), and empathy were not associated with scores on the Triangles Task. However, polygenic scores of cognitive aptitude, and cognitive empathy, a term synonymous with theory of mind and measured using the “Reading the Mind in the Eyes” Test, were significantly associated with scores on the Triangles Task at multiple P-value thresholds, suggesting shared genetics between different measures of theory of mind and cognition.
format	article
author	Varun Warrier Simon Baron-Cohen
author_facet	Varun Warrier Simon Baron-Cohen
author_sort	Varun Warrier
title	Genetic contribution to ‘theory of mind’ in adolescence
title_short	Genetic contribution to ‘theory of mind’ in adolescence
title_full	Genetic contribution to ‘theory of mind’ in adolescence
title_fullStr	Genetic contribution to ‘theory of mind’ in adolescence
title_full_unstemmed	Genetic contribution to ‘theory of mind’ in adolescence
title_sort	genetic contribution to ‘theory of mind’ in adolescence
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/180e8d4ea1dc4c2b9ced2ff46ae71a4c
work_keys_str_mv	AT varunwarrier geneticcontributiontotheoryofmindinadolescence AT simonbaroncohen geneticcontributiontotheoryofmindinadolescence
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Genetic contribution to ‘theory of mind’ in adolescence

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