Connectivity modulations induced by reach&grasp movements: a multidimensional approach

Abstract Reach&grasp requires highly coordinated activation of different brain areas. We investigated whether reach&grasp kinematics is associated to EEG-based networks changes. We enrolled 10 healthy subjects. We analyzed the reach&grasp kinematics of 15 reach&grasp movements perfor...

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Autores principales:	Pietro Caliandro, Gloria Menegaz, Chiara Iacovelli, Carmela Conte, Giuseppe Reale, Paolo Calabresi, Silvia F. Storti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/180e93c9eac04e308c0dfb8de74128ec
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spelling	oai:doaj.org-article:180e93c9eac04e308c0dfb8de74128ec2021-12-05T12:16:08ZConnectivity modulations induced by reach&grasp movements: a multidimensional approach10.1038/s41598-021-02458-x2045-2322https://doaj.org/article/180e93c9eac04e308c0dfb8de74128ec2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02458-xhttps://doaj.org/toc/2045-2322Abstract Reach&grasp requires highly coordinated activation of different brain areas. We investigated whether reach&grasp kinematics is associated to EEG-based networks changes. We enrolled 10 healthy subjects. We analyzed the reach&grasp kinematics of 15 reach&grasp movements performed with each upper limb. Simultaneously, we obtained a 64-channel EEG, synchronized with the reach&grasp movement time points. We elaborated EEG signals with EEGLAB 12 in order to obtain event related synchronization/desynchronization (ERS/ERD) and lagged linear coherence between Brodmann areas. Finally, we evaluated network topology via sLORETA software, measuring network local and global efficiency (clustering and path length) and the overall balance (small-worldness). We observed a widespread ERD in α and β bands during reach&grasp, especially in the centro-parietal regions of the hemisphere contralateral to the movement. Regarding functional connectivity, we observed an α lagged linear coherence reduction among Brodmann areas contralateral to the arm involved in the reach&grasp movement. Interestingly, left arm movement determined widespread changes of α lagged linear coherence, specifically among right occipital regions, insular cortex and somatosensory cortex, while the right arm movement exerted a restricted contralateral sensory-motor cortex modulation. Finally, no change between rest and movement was found for clustering, path length and small-worldness. Through a synchronized acquisition, we explored the cortical correlates of the reach&grasp movement. Despite EEG perturbations, suggesting that the non-dominant reach&grasp network has a complex architecture probably linked to the necessity of a higher visual control, the pivotal topological measures of network local and global efficiency remained unaffected.Pietro CaliandroGloria MenegazChiara IacovelliCarmela ConteGiuseppe RealePaolo CalabresiSilvia F. StortiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pietro Caliandro Gloria Menegaz Chiara Iacovelli Carmela Conte Giuseppe Reale Paolo Calabresi Silvia F. Storti Connectivity modulations induced by reach&grasp movements: a multidimensional approach
description	Abstract Reach&grasp requires highly coordinated activation of different brain areas. We investigated whether reach&grasp kinematics is associated to EEG-based networks changes. We enrolled 10 healthy subjects. We analyzed the reach&grasp kinematics of 15 reach&grasp movements performed with each upper limb. Simultaneously, we obtained a 64-channel EEG, synchronized with the reach&grasp movement time points. We elaborated EEG signals with EEGLAB 12 in order to obtain event related synchronization/desynchronization (ERS/ERD) and lagged linear coherence between Brodmann areas. Finally, we evaluated network topology via sLORETA software, measuring network local and global efficiency (clustering and path length) and the overall balance (small-worldness). We observed a widespread ERD in α and β bands during reach&grasp, especially in the centro-parietal regions of the hemisphere contralateral to the movement. Regarding functional connectivity, we observed an α lagged linear coherence reduction among Brodmann areas contralateral to the arm involved in the reach&grasp movement. Interestingly, left arm movement determined widespread changes of α lagged linear coherence, specifically among right occipital regions, insular cortex and somatosensory cortex, while the right arm movement exerted a restricted contralateral sensory-motor cortex modulation. Finally, no change between rest and movement was found for clustering, path length and small-worldness. Through a synchronized acquisition, we explored the cortical correlates of the reach&grasp movement. Despite EEG perturbations, suggesting that the non-dominant reach&grasp network has a complex architecture probably linked to the necessity of a higher visual control, the pivotal topological measures of network local and global efficiency remained unaffected.
format	article
author	Pietro Caliandro Gloria Menegaz Chiara Iacovelli Carmela Conte Giuseppe Reale Paolo Calabresi Silvia F. Storti
author_facet	Pietro Caliandro Gloria Menegaz Chiara Iacovelli Carmela Conte Giuseppe Reale Paolo Calabresi Silvia F. Storti
author_sort	Pietro Caliandro
title	Connectivity modulations induced by reach&grasp movements: a multidimensional approach
title_short	Connectivity modulations induced by reach&grasp movements: a multidimensional approach
title_full	Connectivity modulations induced by reach&grasp movements: a multidimensional approach
title_fullStr	Connectivity modulations induced by reach&grasp movements: a multidimensional approach
title_full_unstemmed	Connectivity modulations induced by reach&grasp movements: a multidimensional approach
title_sort	connectivity modulations induced by reach&grasp movements: a multidimensional approach
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/180e93c9eac04e308c0dfb8de74128ec
work_keys_str_mv	AT pietrocaliandro connectivitymodulationsinducedbyreachgraspmovementsamultidimensionalapproach AT gloriamenegaz connectivitymodulationsinducedbyreachgraspmovementsamultidimensionalapproach AT chiaraiacovelli connectivitymodulationsinducedbyreachgraspmovementsamultidimensionalapproach AT carmelaconte connectivitymodulationsinducedbyreachgraspmovementsamultidimensionalapproach AT giuseppereale connectivitymodulationsinducedbyreachgraspmovementsamultidimensionalapproach AT paolocalabresi connectivitymodulationsinducedbyreachgraspmovementsamultidimensionalapproach AT silviafstorti connectivitymodulationsinducedbyreachgraspmovementsamultidimensionalapproach
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Connectivity modulations induced by reach&grasp movements: a multidimensional approach

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