TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis

The pathogenesis of paradoxical psoriasis in patients receiving anti-TNF treatments for classical psoriasis is unclear. Here, the authors show that anti-TNF drugs enhance the production of type I interferon by plasmacytoid dendritic cells, causing skin lesions that, unlike classical psoriasis, lack...

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Autores principales:	Curdin Conrad, Jeremy Di Domizio, Alessio Mylonas, Cyrine Belkhodja, Olivier Demaria, Alexander A. Navarini, Anne-Karine Lapointe, Lars E. French, Maxime Vernez, Michel Gilliet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/180fc992d72e4fcbbf1d606055e86015
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spelling	oai:doaj.org-article:180fc992d72e4fcbbf1d606055e860152021-12-02T16:49:24ZTNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis10.1038/s41467-017-02466-42041-1723https://doaj.org/article/180fc992d72e4fcbbf1d606055e860152018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02466-4https://doaj.org/toc/2041-1723The pathogenesis of paradoxical psoriasis in patients receiving anti-TNF treatments for classical psoriasis is unclear. Here, the authors show that anti-TNF drugs enhance the production of type I interferon by plasmacytoid dendritic cells, causing skin lesions that, unlike classical psoriasis, lack T- cell autoimmunity.Curdin ConradJeremy Di DomizioAlessio MylonasCyrine BelkhodjaOlivier DemariaAlexander A. NavariniAnne-Karine LapointeLars E. FrenchMaxime VernezMichel GillietNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Curdin Conrad Jeremy Di Domizio Alessio Mylonas Cyrine Belkhodja Olivier Demaria Alexander A. Navarini Anne-Karine Lapointe Lars E. French Maxime Vernez Michel Gilliet TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis
description	The pathogenesis of paradoxical psoriasis in patients receiving anti-TNF treatments for classical psoriasis is unclear. Here, the authors show that anti-TNF drugs enhance the production of type I interferon by plasmacytoid dendritic cells, causing skin lesions that, unlike classical psoriasis, lack T- cell autoimmunity.
format	article
author	Curdin Conrad Jeremy Di Domizio Alessio Mylonas Cyrine Belkhodja Olivier Demaria Alexander A. Navarini Anne-Karine Lapointe Lars E. French Maxime Vernez Michel Gilliet
author_facet	Curdin Conrad Jeremy Di Domizio Alessio Mylonas Cyrine Belkhodja Olivier Demaria Alexander A. Navarini Anne-Karine Lapointe Lars E. French Maxime Vernez Michel Gilliet
author_sort	Curdin Conrad
title	TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis
title_short	TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis
title_full	TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis
title_fullStr	TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis
title_full_unstemmed	TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis
title_sort	tnf blockade induces a dysregulated type i interferon response without autoimmunity in paradoxical psoriasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/180fc992d72e4fcbbf1d606055e86015
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TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis

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