circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis

Abstract Circular RNAs (circRNAs) play essential roles in human bladder cancer (BCa) development, however, unusual expression patterns and functional dysfunction of circRNAs in BCa have not been evaluated. In this study, we validated that circKDM4C (hsa_circ_0001839), derived from the KDM4C gene, is...

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Autores principales:	Xueyou Ma, Yufan Ying, Jiazhu Sun, Haiyun Xie, Jiangfeng Li, Liujia He, Weiyu Wang, Shiming Chen, Haixiang Shen, Jiahe Yi, Jindan Luo, Xiao Wang, Xiangyi Zheng, Ben Liu, Liping Xie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/1810758580114f129f2ac53bda4d4f1c
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spelling	oai:doaj.org-article:1810758580114f129f2ac53bda4d4f1c2021-11-28T12:10:40ZcircKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis10.1038/s41420-021-00712-92058-7716https://doaj.org/article/1810758580114f129f2ac53bda4d4f1c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41420-021-00712-9https://doaj.org/toc/2058-7716Abstract Circular RNAs (circRNAs) play essential roles in human bladder cancer (BCa) development, however, unusual expression patterns and functional dysfunction of circRNAs in BCa have not been evaluated. In this study, we validated that circKDM4C (hsa_circ_0001839), derived from the KDM4C gene, is elevated in BCa cell lines as well as tissues. Functionally, overexpression of circKDM4C significantly enhances, and silencing of circKDM4C suppresses migration and invasion capabilities of BCa cells. Mechanistically, circKDM4C can directly interact with miR-200b-3p and miR-200c-3p as a miRNA sponge, which enhances the expression of ZEB1 and promotes mesenchymal phenotype. Conclusively, our findings indicate that circKDM4C may act as a pro-oncogenic factor in BCa invasion and metastasis via the circKDM4C/miR-200bc-3p/ZEB1 axis, which is a potential biomarker or therapeutic target for bladder cancer.Xueyou MaYufan YingJiazhu SunHaiyun XieJiangfeng LiLiujia HeWeiyu WangShiming ChenHaixiang ShenJiahe YiJindan LuoXiao WangXiangyi ZhengBen LiuLiping XieNature Publishing GrouparticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Xueyou Ma Yufan Ying Jiazhu Sun Haiyun Xie Jiangfeng Li Liujia He Weiyu Wang Shiming Chen Haixiang Shen Jiahe Yi Jindan Luo Xiao Wang Xiangyi Zheng Ben Liu Liping Xie circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis
description	Abstract Circular RNAs (circRNAs) play essential roles in human bladder cancer (BCa) development, however, unusual expression patterns and functional dysfunction of circRNAs in BCa have not been evaluated. In this study, we validated that circKDM4C (hsa_circ_0001839), derived from the KDM4C gene, is elevated in BCa cell lines as well as tissues. Functionally, overexpression of circKDM4C significantly enhances, and silencing of circKDM4C suppresses migration and invasion capabilities of BCa cells. Mechanistically, circKDM4C can directly interact with miR-200b-3p and miR-200c-3p as a miRNA sponge, which enhances the expression of ZEB1 and promotes mesenchymal phenotype. Conclusively, our findings indicate that circKDM4C may act as a pro-oncogenic factor in BCa invasion and metastasis via the circKDM4C/miR-200bc-3p/ZEB1 axis, which is a potential biomarker or therapeutic target for bladder cancer.
format	article
author	Xueyou Ma Yufan Ying Jiazhu Sun Haiyun Xie Jiangfeng Li Liujia He Weiyu Wang Shiming Chen Haixiang Shen Jiahe Yi Jindan Luo Xiao Wang Xiangyi Zheng Ben Liu Liping Xie
author_facet	Xueyou Ma Yufan Ying Jiazhu Sun Haiyun Xie Jiangfeng Li Liujia He Weiyu Wang Shiming Chen Haixiang Shen Jiahe Yi Jindan Luo Xiao Wang Xiangyi Zheng Ben Liu Liping Xie
author_sort	Xueyou Ma
title	circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis
title_short	circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis
title_full	circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis
title_fullStr	circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis
title_full_unstemmed	circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis
title_sort	circkdm4c enhances bladder cancer invasion and metastasis through mir-200bc-3p/zeb1 axis
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/1810758580114f129f2ac53bda4d4f1c
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circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis

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