TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy

Xenophage, or autophagy directed against pathogens, might be involved in the clearance of bacterial infection, but the mechanism is unclear. Here, the authors show that ubiquitinated bacteria are bound by TBC1D9 via a Ca2+-dependent interaction to induce downstream activation of TBK1 signalling and...

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Autores principales:	Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/181094b3d4dc4048b7968139d1016659
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spelling	oai:doaj.org-article:181094b3d4dc4048b7968139d10166592021-12-02T17:32:43ZTBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy10.1038/s41467-020-14533-42041-1723https://doaj.org/article/181094b3d4dc4048b7968139d10166592020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14533-4https://doaj.org/toc/2041-1723Xenophage, or autophagy directed against pathogens, might be involved in the clearance of bacterial infection, but the mechanism is unclear. Here, the authors show that ubiquitinated bacteria are bound by TBC1D9 via a Ca2+-dependent interaction to induce downstream activation of TBK1 signalling and xenophagy, as well as mitophagy.Takashi NozawaShunsuke SanoAtsuko Minowa-NozawaHirotaka TohShintaro NakajimaKazunori MuraseChihiro AikawaIchiro NakagawaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takashi Nozawa Shunsuke Sano Atsuko Minowa-Nozawa Hirotaka Toh Shintaro Nakajima Kazunori Murase Chihiro Aikawa Ichiro Nakagawa TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy
description	Xenophage, or autophagy directed against pathogens, might be involved in the clearance of bacterial infection, but the mechanism is unclear. Here, the authors show that ubiquitinated bacteria are bound by TBC1D9 via a Ca2+-dependent interaction to induce downstream activation of TBK1 signalling and xenophagy, as well as mitophagy.
format	article
author	Takashi Nozawa Shunsuke Sano Atsuko Minowa-Nozawa Hirotaka Toh Shintaro Nakajima Kazunori Murase Chihiro Aikawa Ichiro Nakagawa
author_facet	Takashi Nozawa Shunsuke Sano Atsuko Minowa-Nozawa Hirotaka Toh Shintaro Nakajima Kazunori Murase Chihiro Aikawa Ichiro Nakagawa
author_sort	Takashi Nozawa
title	TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy
title_short	TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy
title_full	TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy
title_fullStr	TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy
title_full_unstemmed	TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy
title_sort	tbc1d9 regulates tbk1 activation through ca2+ signaling in selective autophagy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/181094b3d4dc4048b7968139d1016659
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_version_	1718380171131617280

TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy

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