Tear film break-up patterns in thyroid eye disease

Abstract Evaluation of tear film break-up pattern (TFBUP) is the main diagnostic method for tear film-oriented therapy (TFOT) of dry eye. This prospective, observational study examined TFBUPs in 154 eyes/sides from 78 patients with thyroid eye disease (TED) who met the diagnostic criteria for dry ey...

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Autores principales:	Yasuhiro Takahashi, Patricia Ann L. Lee, Aric Vaidya, Shinjiro Kono, Hirohiko Kakizaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1815ba93999b4e3a9ef315408c3bdaf1
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spelling	oai:doaj.org-article:1815ba93999b4e3a9ef315408c3bdaf12021-12-02T13:19:21ZTear film break-up patterns in thyroid eye disease10.1038/s41598-021-84661-42045-2322https://doaj.org/article/1815ba93999b4e3a9ef315408c3bdaf12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84661-4https://doaj.org/toc/2045-2322Abstract Evaluation of tear film break-up pattern (TFBUP) is the main diagnostic method for tear film-oriented therapy (TFOT) of dry eye. This prospective, observational study examined TFBUPs in 154 eyes/sides from 78 patients with thyroid eye disease (TED) who met the diagnostic criteria for dry eye in Japan. TFBUPs were classified as area, line, spot, dimple, and random breaks. Results for the status of TED and dry eye were compared between the TFBUPs. Consequently, line, spot, dimple, and random breaks were observed in 80 (51.9%), 29 (18.8%), 10 (6.5%), and 35 eyes (22.7%) while no eyes showed area breaks. The random break group had the highest incidence of lid lag/Graefe sign and superior limbic keratoconjunctivitis (SLK) (P < 0.050). Although the incidence of each TFBUP is almost equal in patients with simple dry eye without TED, line breaks were more frequently observed in TED. In addition, while random breaks in simple dry eye are usually only associated with minor ocular surface damages, those in TED were associated with a higher incidence of concomitant SLK. These results will be helpful for understanding the etiology of dry eye in TED and for TFOT in TED.Yasuhiro TakahashiPatricia Ann L. LeeAric VaidyaShinjiro KonoHirohiko KakizakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yasuhiro Takahashi Patricia Ann L. Lee Aric Vaidya Shinjiro Kono Hirohiko Kakizaki Tear film break-up patterns in thyroid eye disease
description	Abstract Evaluation of tear film break-up pattern (TFBUP) is the main diagnostic method for tear film-oriented therapy (TFOT) of dry eye. This prospective, observational study examined TFBUPs in 154 eyes/sides from 78 patients with thyroid eye disease (TED) who met the diagnostic criteria for dry eye in Japan. TFBUPs were classified as area, line, spot, dimple, and random breaks. Results for the status of TED and dry eye were compared between the TFBUPs. Consequently, line, spot, dimple, and random breaks were observed in 80 (51.9%), 29 (18.8%), 10 (6.5%), and 35 eyes (22.7%) while no eyes showed area breaks. The random break group had the highest incidence of lid lag/Graefe sign and superior limbic keratoconjunctivitis (SLK) (P < 0.050). Although the incidence of each TFBUP is almost equal in patients with simple dry eye without TED, line breaks were more frequently observed in TED. In addition, while random breaks in simple dry eye are usually only associated with minor ocular surface damages, those in TED were associated with a higher incidence of concomitant SLK. These results will be helpful for understanding the etiology of dry eye in TED and for TFOT in TED.
format	article
author	Yasuhiro Takahashi Patricia Ann L. Lee Aric Vaidya Shinjiro Kono Hirohiko Kakizaki
author_facet	Yasuhiro Takahashi Patricia Ann L. Lee Aric Vaidya Shinjiro Kono Hirohiko Kakizaki
author_sort	Yasuhiro Takahashi
title	Tear film break-up patterns in thyroid eye disease
title_short	Tear film break-up patterns in thyroid eye disease
title_full	Tear film break-up patterns in thyroid eye disease
title_fullStr	Tear film break-up patterns in thyroid eye disease
title_full_unstemmed	Tear film break-up patterns in thyroid eye disease
title_sort	tear film break-up patterns in thyroid eye disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1815ba93999b4e3a9ef315408c3bdaf1
work_keys_str_mv	AT yasuhirotakahashi tearfilmbreakuppatternsinthyroideyedisease AT patriciaannllee tearfilmbreakuppatternsinthyroideyedisease AT aricvaidya tearfilmbreakuppatternsinthyroideyedisease AT shinjirokono tearfilmbreakuppatternsinthyroideyedisease AT hirohikokakizaki tearfilmbreakuppatternsinthyroideyedisease
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Tear film break-up patterns in thyroid eye disease

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