Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis

Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis

Abstract A direct link between Ca2+ and lipid homeostasis has not been definitively demonstrated. In this study, we show that manipulation of ER Ca2+ causes the re-distribution of a portion of the intracellular unesterified cholesterol to a pool that is not available to the SCAP-SREBP complex. The S...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Wen-An Wang, Wen-Xin Liu, Serpen Durnaoglu, Sun-Kyung Lee, Jihong Lian, Richard Lehner, Joohong Ahnn, Luis B. Agellon, Marek Michalak
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/181ac3ffb8594bf0b12bfef6d8cefed5
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares