Lower Cardiorespiratory Fitness Is Associated With Right Ventricular Geometry and Function – The Sedentary’s Heart: SHIP
Background Lower cardiorespiratory fitness (CRF) is associated with an increased risk for cardiovascular disease. However, very little information is available about the association between lower CRF and right ventricular (RV) remodeling. We investigated the relationship between CRF and RV structure...
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Wiley
2021
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oai:doaj.org-article:181eb66fa3164edfa3e45c065aa7ccc72021-11-16T10:22:43ZLower Cardiorespiratory Fitness Is Associated With Right Ventricular Geometry and Function – The Sedentary’s Heart: SHIP10.1161/JAHA.120.0211162047-9980https://doaj.org/article/181eb66fa3164edfa3e45c065aa7ccc72021-11-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.120.021116https://doaj.org/toc/2047-9980Background Lower cardiorespiratory fitness (CRF) is associated with an increased risk for cardiovascular disease. However, very little information is available about the association between lower CRF and right ventricular (RV) remodeling. We investigated the relationship between CRF and RV structure and function in a large, aging, and largely sedentary adult population–based cohort. Methods and Results We used cross‐sectional data of 2844 subjects (1486 women; median age, 51 years; interquartile range, 40–62 years) from the population‐based cohort SHIP (Study of Health in Pomerania) with echocardiography, of which 941 also had cardiac magnetic resonance imaging. We analyzed the associations of peak oxygen uptake with RV parameters determined by both imaging techniques using multivariable‐adjusted linear regression models. In echocardiography, a 1 L/min lower peak oxygen uptake was associated with a 1.18 mm (95% CI, 0.66–1.71; P<0.001) smaller RV end‐diastolic diameter and a 1.41 mm (95% CI, 0.90–1.92; P<0.001) narrower RV end‐diastolic outflow tract diameter. Similarly, using cardiac magnetic resonance imaging measurements, a 1 L/min lower peak oxygen uptake was associated with a 23.5 mL (95% CI, 18.7–28.4; P<0.001) smaller RV end‐diastolic volume, a 13.0 mL (95% CI, 9.81–16.2; P<0.001) lower RV end‐systolic volume, and a 10.7 mL/beat (95% CI, 8.10–13.3; P<0.001) lower RV stroke volume. Conclusions Our results indicate a significant association between CRF and RV remodeling. Lower CRF was associated with smaller RV chamber and lower RV systolic function, stroke volume, and cardiac output.Christine J. DrzyzgaMartin BahlsTill IttermannHenry VölzkeRobin BülowFabian HammerRalf EwertSven GläserStephan B. FelixMarcus DörrMarcello R. P. MarkusWileyarticlecardiorespiratory fitnesspeak oxygen uptakephysical inactivityright ventricular geometry and functionright ventricular volumesDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
cardiorespiratory fitness peak oxygen uptake physical inactivity right ventricular geometry and function right ventricular volumes Diseases of the circulatory (Cardiovascular) system RC666-701 |
| spellingShingle |
cardiorespiratory fitness peak oxygen uptake physical inactivity right ventricular geometry and function right ventricular volumes Diseases of the circulatory (Cardiovascular) system RC666-701 Christine J. Drzyzga Martin Bahls Till Ittermann Henry Völzke Robin Bülow Fabian Hammer Ralf Ewert Sven Gläser Stephan B. Felix Marcus Dörr Marcello R. P. Markus Lower Cardiorespiratory Fitness Is Associated With Right Ventricular Geometry and Function – The Sedentary’s Heart: SHIP |
| description |
Background Lower cardiorespiratory fitness (CRF) is associated with an increased risk for cardiovascular disease. However, very little information is available about the association between lower CRF and right ventricular (RV) remodeling. We investigated the relationship between CRF and RV structure and function in a large, aging, and largely sedentary adult population–based cohort. Methods and Results We used cross‐sectional data of 2844 subjects (1486 women; median age, 51 years; interquartile range, 40–62 years) from the population‐based cohort SHIP (Study of Health in Pomerania) with echocardiography, of which 941 also had cardiac magnetic resonance imaging. We analyzed the associations of peak oxygen uptake with RV parameters determined by both imaging techniques using multivariable‐adjusted linear regression models. In echocardiography, a 1 L/min lower peak oxygen uptake was associated with a 1.18 mm (95% CI, 0.66–1.71; P<0.001) smaller RV end‐diastolic diameter and a 1.41 mm (95% CI, 0.90–1.92; P<0.001) narrower RV end‐diastolic outflow tract diameter. Similarly, using cardiac magnetic resonance imaging measurements, a 1 L/min lower peak oxygen uptake was associated with a 23.5 mL (95% CI, 18.7–28.4; P<0.001) smaller RV end‐diastolic volume, a 13.0 mL (95% CI, 9.81–16.2; P<0.001) lower RV end‐systolic volume, and a 10.7 mL/beat (95% CI, 8.10–13.3; P<0.001) lower RV stroke volume. Conclusions Our results indicate a significant association between CRF and RV remodeling. Lower CRF was associated with smaller RV chamber and lower RV systolic function, stroke volume, and cardiac output. |
| format |
article |
| author |
Christine J. Drzyzga Martin Bahls Till Ittermann Henry Völzke Robin Bülow Fabian Hammer Ralf Ewert Sven Gläser Stephan B. Felix Marcus Dörr Marcello R. P. Markus |
| author_facet |
Christine J. Drzyzga Martin Bahls Till Ittermann Henry Völzke Robin Bülow Fabian Hammer Ralf Ewert Sven Gläser Stephan B. Felix Marcus Dörr Marcello R. P. Markus |
| author_sort |
Christine J. Drzyzga |
| title |
Lower Cardiorespiratory Fitness Is Associated With Right Ventricular Geometry and Function – The Sedentary’s Heart: SHIP |
| title_short |
Lower Cardiorespiratory Fitness Is Associated With Right Ventricular Geometry and Function – The Sedentary’s Heart: SHIP |
| title_full |
Lower Cardiorespiratory Fitness Is Associated With Right Ventricular Geometry and Function – The Sedentary’s Heart: SHIP |
| title_fullStr |
Lower Cardiorespiratory Fitness Is Associated With Right Ventricular Geometry and Function – The Sedentary’s Heart: SHIP |
| title_full_unstemmed |
Lower Cardiorespiratory Fitness Is Associated With Right Ventricular Geometry and Function – The Sedentary’s Heart: SHIP |
| title_sort |
lower cardiorespiratory fitness is associated with right ventricular geometry and function – the sedentary’s heart: ship |
| publisher |
Wiley |
| publishDate |
2021 |
| url |
https://doaj.org/article/181eb66fa3164edfa3e45c065aa7ccc7 |
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