Identification of Significant Predictors for the Need of Insulin Therapy and Onset of Postpartum Impaired Glucose Tolerance in Gestational Diabetes Mellitus Patients

Ting Wang,1,2 Wei Yin,3 Yonghan Huang,2 Qingxue Zhang1 1Department of Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Reproductive Medicine Center, The First People’s Hospital of Foshan(Aff...

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Autores principales:	Wang T, Yin W, Huang Y, Zhang Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	insulin glucose diabetes pregnancy postpartum Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/18209a08e4b142a7bdaa6d9bd1e36123
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spelling	oai:doaj.org-article:18209a08e4b142a7bdaa6d9bd1e361232021-12-02T18:05:41ZIdentification of Significant Predictors for the Need of Insulin Therapy and Onset of Postpartum Impaired Glucose Tolerance in Gestational Diabetes Mellitus Patients1178-7007https://doaj.org/article/18209a08e4b142a7bdaa6d9bd1e361232021-06-01T00:00:00Zhttps://www.dovepress.com/identification-of-significant-predictors-for-the-need-of-insulin-thera-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Ting Wang,1,2 Wei Yin,3 Yonghan Huang,2 Qingxue Zhang1 1Department of Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Reproductive Medicine Center, The First People’s Hospital of Foshan(Affiliated FoShan Hospital of Sun Yat-sen University), Foshan, People’s Republic of China; 3Department of Obstetrics, Guangzhou Women and Children’s Center, Guangzhou, People’s Republic of ChinaCorrespondence: Qingxue Zhang Email qingxuezhang.sysu@outlook.comBackground: Gestational diabetes mellitus (GDM) during pregnancy can greatly increase the risk for a number of adverse prenatal and postpartum consequences, including postpartum impaired glucose tolerance (IGT). Determining the need for insulin therapy is critical for controlling the glycemic level in GDM patients. The study contains two major purposes: 1) to identify the potential predictors for the need of insulin therapy in GDM patients; 2) to identify the factors that are related to the onset of postpartum IGT.Materials and Methods: Here, we performed a retrospective study on 112 GDM patients in China to identify the significant predictors for the need of insulin therapy and onset of postpartum IGT in patients with GDM.Results: Age and gestational weeks at GDM diagnosis, pregestational BMI, family history of diabetes mellitus (DM), plasma glucose levels assessed by 75-g OGTT at both the 1-hour and 2-hour time points (PG-1h and PG-2h) and HbA1c level were all significantly different between the patients that received insulin therapy and those did not. During postpartum, family history of DM, PG-1h PG-2h and HbA1c level were found to be significantly different between the patients with normal glucose tolerance and those with IGT.Conclusion: Our results reveal a number of factors that are closely associated with the need of insulin therapy and onset of postpartum IGT, especially the PG-1h and PG-2h levels. These findings will provide valuable indications on selection of treatment strategy for GDM and GDM-induced postpartum IGT.Keywords: insulin, glucose, diabetes, pregnancy, postpartumWang TYin WHuang YZhang QDove Medical PressarticleinsulinglucosediabetespregnancypostpartumSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2609-2617 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	insulin glucose diabetes pregnancy postpartum Specialties of internal medicine RC581-951
spellingShingle	insulin glucose diabetes pregnancy postpartum Specialties of internal medicine RC581-951 Wang T Yin W Huang Y Zhang Q Identification of Significant Predictors for the Need of Insulin Therapy and Onset of Postpartum Impaired Glucose Tolerance in Gestational Diabetes Mellitus Patients
description	Ting Wang,1,2 Wei Yin,3 Yonghan Huang,2 Qingxue Zhang1 1Department of Reproductive Medicine Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Reproductive Medicine Center, The First People’s Hospital of Foshan(Affiliated FoShan Hospital of Sun Yat-sen University), Foshan, People’s Republic of China; 3Department of Obstetrics, Guangzhou Women and Children’s Center, Guangzhou, People’s Republic of ChinaCorrespondence: Qingxue Zhang Email qingxuezhang.sysu@outlook.comBackground: Gestational diabetes mellitus (GDM) during pregnancy can greatly increase the risk for a number of adverse prenatal and postpartum consequences, including postpartum impaired glucose tolerance (IGT). Determining the need for insulin therapy is critical for controlling the glycemic level in GDM patients. The study contains two major purposes: 1) to identify the potential predictors for the need of insulin therapy in GDM patients; 2) to identify the factors that are related to the onset of postpartum IGT.Materials and Methods: Here, we performed a retrospective study on 112 GDM patients in China to identify the significant predictors for the need of insulin therapy and onset of postpartum IGT in patients with GDM.Results: Age and gestational weeks at GDM diagnosis, pregestational BMI, family history of diabetes mellitus (DM), plasma glucose levels assessed by 75-g OGTT at both the 1-hour and 2-hour time points (PG-1h and PG-2h) and HbA1c level were all significantly different between the patients that received insulin therapy and those did not. During postpartum, family history of DM, PG-1h PG-2h and HbA1c level were found to be significantly different between the patients with normal glucose tolerance and those with IGT.Conclusion: Our results reveal a number of factors that are closely associated with the need of insulin therapy and onset of postpartum IGT, especially the PG-1h and PG-2h levels. These findings will provide valuable indications on selection of treatment strategy for GDM and GDM-induced postpartum IGT.Keywords: insulin, glucose, diabetes, pregnancy, postpartum
format	article
author	Wang T Yin W Huang Y Zhang Q
author_facet	Wang T Yin W Huang Y Zhang Q
author_sort	Wang T
title	Identification of Significant Predictors for the Need of Insulin Therapy and Onset of Postpartum Impaired Glucose Tolerance in Gestational Diabetes Mellitus Patients
title_short	Identification of Significant Predictors for the Need of Insulin Therapy and Onset of Postpartum Impaired Glucose Tolerance in Gestational Diabetes Mellitus Patients
title_full	Identification of Significant Predictors for the Need of Insulin Therapy and Onset of Postpartum Impaired Glucose Tolerance in Gestational Diabetes Mellitus Patients
title_fullStr	Identification of Significant Predictors for the Need of Insulin Therapy and Onset of Postpartum Impaired Glucose Tolerance in Gestational Diabetes Mellitus Patients
title_full_unstemmed	Identification of Significant Predictors for the Need of Insulin Therapy and Onset of Postpartum Impaired Glucose Tolerance in Gestational Diabetes Mellitus Patients
title_sort	identification of significant predictors for the need of insulin therapy and onset of postpartum impaired glucose tolerance in gestational diabetes mellitus patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/18209a08e4b142a7bdaa6d9bd1e36123
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Identification of Significant Predictors for the Need of Insulin Therapy and Onset of Postpartum Impaired Glucose Tolerance in Gestational Diabetes Mellitus Patients

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