Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.

<h4>Background</h4>New agents with neuroprotective or neuroregenerative potential might be explored in primary-progressive Multiple Sclerosis (PPMS)--the MS disease course with leading neurodegenerative pathology. Identification of patients with a high short-term risk for progression may...

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Autores principales:	Jan-Patrick Stellmann, Anneke Neuhaus, Christian Lederer, Martin Daumer, Christoph Heesen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/18251039226e4f86b3d219c7fbe9fd0e
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spelling	oai:doaj.org-article:18251039226e4f86b3d219c7fbe9fd0e2021-11-18T08:27:06ZValidating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.1932-620310.1371/journal.pone.0092761https://doaj.org/article/18251039226e4f86b3d219c7fbe9fd0e2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24651401/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>New agents with neuroprotective or neuroregenerative potential might be explored in primary-progressive Multiple Sclerosis (PPMS)--the MS disease course with leading neurodegenerative pathology. Identification of patients with a high short-term risk for progression may minimize study duration and sample size. Cohort studies reported several variables as predictors of EDSS disability progression but findings were partially contradictory.<h4>Objective</h4>To analyse the impact of published predictors on EDSS disease progression in a large cohort of PPMS patients.<h4>Methods</h4>A systematic literature research was performed to identify predictors for disease progression in PPMS. Individual case data from the Sylvia Lawry Centre (SLC) and the Hamburg MS patient database (HAPIMS) was pooled for a retrospective validation of these predictors on the annualized EDSS change.<h4>Results</h4>The systematic literature analysis revealed heterogeneous data from 3 prospective and 5 retrospective natural history cohort studies. Age at onset, gender, type of first symptoms and early EDSS changes were available for validation. Our pooled cohort of 597 PPMS patients (54% female) had a mean follow-up of 4.4 years and mean change of EDSS of 0.35 per year based on 2503 EDSS assessments. There was no significant association between the investigated variables and the EDSS-change.<h4>Conclusion</h4>None of the analysed variables were predictive for the disease progression measured by the annualized EDSS change. Whether PPMS is still unpredictable or our results may be due to limitations of cohort assessments or selection of predictors cannot be answered. Large systematic prospective studies with new endpoints are needed.Jan-Patrick StellmannAnneke NeuhausChristian LedererMartin DaumerChristoph HeesenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e92761 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jan-Patrick Stellmann Anneke Neuhaus Christian Lederer Martin Daumer Christoph Heesen Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.
description	<h4>Background</h4>New agents with neuroprotective or neuroregenerative potential might be explored in primary-progressive Multiple Sclerosis (PPMS)--the MS disease course with leading neurodegenerative pathology. Identification of patients with a high short-term risk for progression may minimize study duration and sample size. Cohort studies reported several variables as predictors of EDSS disability progression but findings were partially contradictory.<h4>Objective</h4>To analyse the impact of published predictors on EDSS disease progression in a large cohort of PPMS patients.<h4>Methods</h4>A systematic literature research was performed to identify predictors for disease progression in PPMS. Individual case data from the Sylvia Lawry Centre (SLC) and the Hamburg MS patient database (HAPIMS) was pooled for a retrospective validation of these predictors on the annualized EDSS change.<h4>Results</h4>The systematic literature analysis revealed heterogeneous data from 3 prospective and 5 retrospective natural history cohort studies. Age at onset, gender, type of first symptoms and early EDSS changes were available for validation. Our pooled cohort of 597 PPMS patients (54% female) had a mean follow-up of 4.4 years and mean change of EDSS of 0.35 per year based on 2503 EDSS assessments. There was no significant association between the investigated variables and the EDSS-change.<h4>Conclusion</h4>None of the analysed variables were predictive for the disease progression measured by the annualized EDSS change. Whether PPMS is still unpredictable or our results may be due to limitations of cohort assessments or selection of predictors cannot be answered. Large systematic prospective studies with new endpoints are needed.
format	article
author	Jan-Patrick Stellmann Anneke Neuhaus Christian Lederer Martin Daumer Christoph Heesen
author_facet	Jan-Patrick Stellmann Anneke Neuhaus Christian Lederer Martin Daumer Christoph Heesen
author_sort	Jan-Patrick Stellmann
title	Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.
title_short	Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.
title_full	Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.
title_fullStr	Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.
title_full_unstemmed	Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.
title_sort	validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/18251039226e4f86b3d219c7fbe9fd0e
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Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.

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