Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring

Abstract The association between Zika virus (ZIKV) infection and congenital malformations such as microcephaly in infants is a public health emergency. Although various in vivo and in vitro models are used for ZIKV research, few animal models are available for resolving the effects of maternal ZIKV...

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Autores principales:	Yingchao Shi, Shihua Li, Qian Wu, Le Sun, Junjing Zhang, Na Pan, Qihui Wang, Yuhai Bi, Jing An, Xuancheng Lu, George Fu Gao, Xiaoqun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/18252ce390154f0f8e80eec707af156b
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spelling	oai:doaj.org-article:18252ce390154f0f8e80eec707af156b2021-12-02T11:41:25ZVertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring10.1038/s41598-018-21894-w2045-2322https://doaj.org/article/18252ce390154f0f8e80eec707af156b2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21894-whttps://doaj.org/toc/2045-2322Abstract The association between Zika virus (ZIKV) infection and congenital malformations such as microcephaly in infants is a public health emergency. Although various in vivo and in vitro models are used for ZIKV research, few animal models are available for resolving the effects of maternal ZIKV infection on neonatal development. Here, we established an immunocompetent mouse model via intrauterine inoculation. Our results confirmed that ZIKV, but not dengue virus, infection caused spontaneous abortions, brain malformations, ocular abnormalities, spinal cord defects and paralysis in mouse offspring. Aside from microcephaly and hippocampal dysplasia, eye abnormalities, including microphthalmia, thinner optic nerves, damaged retinae, and deficient visual projection, were also observed following ZIKV infection. Moreover, ZIKV-infected offspring showed a loss of alpha motor neurons in the spinal cord and cerebellar malformation, which may cause paralysis. ZIKV also impaired adult neurogenesis in neonatal mice. Due to its intact immunity, our rodent model can be used to systematically evaluate the impact of ZIKV on embryonic and neonatal development and to explore potential therapies.Yingchao ShiShihua LiQian WuLe SunJunjing ZhangNa PanQihui WangYuhai BiJing AnXuancheng LuGeorge Fu GaoXiaoqun WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yingchao Shi Shihua Li Qian Wu Le Sun Junjing Zhang Na Pan Qihui Wang Yuhai Bi Jing An Xuancheng Lu George Fu Gao Xiaoqun Wang Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring
description	Abstract The association between Zika virus (ZIKV) infection and congenital malformations such as microcephaly in infants is a public health emergency. Although various in vivo and in vitro models are used for ZIKV research, few animal models are available for resolving the effects of maternal ZIKV infection on neonatal development. Here, we established an immunocompetent mouse model via intrauterine inoculation. Our results confirmed that ZIKV, but not dengue virus, infection caused spontaneous abortions, brain malformations, ocular abnormalities, spinal cord defects and paralysis in mouse offspring. Aside from microcephaly and hippocampal dysplasia, eye abnormalities, including microphthalmia, thinner optic nerves, damaged retinae, and deficient visual projection, were also observed following ZIKV infection. Moreover, ZIKV-infected offspring showed a loss of alpha motor neurons in the spinal cord and cerebellar malformation, which may cause paralysis. ZIKV also impaired adult neurogenesis in neonatal mice. Due to its intact immunity, our rodent model can be used to systematically evaluate the impact of ZIKV on embryonic and neonatal development and to explore potential therapies.
format	article
author	Yingchao Shi Shihua Li Qian Wu Le Sun Junjing Zhang Na Pan Qihui Wang Yuhai Bi Jing An Xuancheng Lu George Fu Gao Xiaoqun Wang
author_facet	Yingchao Shi Shihua Li Qian Wu Le Sun Junjing Zhang Na Pan Qihui Wang Yuhai Bi Jing An Xuancheng Lu George Fu Gao Xiaoqun Wang
author_sort	Yingchao Shi
title	Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring
title_short	Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring
title_full	Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring
title_fullStr	Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring
title_full_unstemmed	Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring
title_sort	vertical transmission of the zika virus causes neurological disorders in mouse offspring
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/18252ce390154f0f8e80eec707af156b
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Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring

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