Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014)

Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014)

Michael D Becker, Brian C YoungEmergency and Critical Care, Animal Specialty Group, Los Angeles, CA, USAAbstract: The objective of this retrospective study was to describe the responses to treatment with intravenous lipid emulsion (ILE) and the outcomes for a variety of severe intoxications...

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Autores principales: Becker MD, Young BC
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Intravenous lipid emulsion
toxicity
amlodipine
Veterinary medicine
SF600-1100
Acceso en línea:https://doaj.org/article/182b3400a8c643b688b7599fde96146f
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spelling oai:doaj.org-article:182b3400a8c643b688b7599fde96146f2021-12-02T04:34:01ZTreatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014)2230-2034https://doaj.org/article/182b3400a8c643b688b7599fde96146f2017-10-01T00:00:00Zhttps://www.dovepress.com/treatment-of-severe-lipophilic-intoxications-with-intravenous-lipid-em-peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034Michael D Becker, Brian C YoungEmergency and Critical Care, Animal Specialty Group, Los Angeles, CA, USAAbstract: The objective of this retrospective study was to describe the responses to treatment with intravenous lipid emulsion (ILE) and the outcomes for a variety of severe intoxications. This case series includes 10 client-owned animals, 9 dogs and 1 cat, that underwent treatment with ILE for a variety of severe intoxications over a 4-year period. History, physical examination findings, clinical signs, clinicopathological test results, treatment, response to treatment, and outcome were recorded. Eight of the 10 patients survived to discharge. The toxicities included in this case series were baclofen, ivermectin and spinosad plus milbemycin oxime, baclofen and tadalafil, carbamate, methamphetamine, dextroamphetamine sulfate, amlodipine, bromethalin, and organophosphate. The two patients who died were intoxicated with bromethalin and an organophosphate. Six of the 10 patients developed lipemia secondary to ILE administration, and there were no other known adverse effects. Overall, ILE was a safe therapeutic option. This case series provides clinical evidence of successful treatment with ILE as an antidote for previously unpublished toxicities (amlodipine, carbamate, methamphetamine, and dextroamphetamine sulfate), additional evidence of success in treating baclofen and ivermectin toxicosis, as well as unsuccessful treatment of bromethalin and organophosphate toxicities.Keywords: intravenous lipid emulsion, toxicity, amlodipine Becker MDYoung BCDove Medical PressarticleIntravenous lipid emulsiontoxicityamlodipineVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol Volume 8, Pp 77-85 (2017)
institution DOAJ
collection DOAJ
language EN
topic Intravenous lipid emulsion
toxicity
amlodipine
Veterinary medicine
SF600-1100
spellingShingle Intravenous lipid emulsion
toxicity
amlodipine
Veterinary medicine
SF600-1100
Becker MD
Young BC
Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014)
description Michael D Becker, Brian C YoungEmergency and Critical Care, Animal Specialty Group, Los Angeles, CA, USAAbstract: The objective of this retrospective study was to describe the responses to treatment with intravenous lipid emulsion (ILE) and the outcomes for a variety of severe intoxications. This case series includes 10 client-owned animals, 9 dogs and 1 cat, that underwent treatment with ILE for a variety of severe intoxications over a 4-year period. History, physical examination findings, clinical signs, clinicopathological test results, treatment, response to treatment, and outcome were recorded. Eight of the 10 patients survived to discharge. The toxicities included in this case series were baclofen, ivermectin and spinosad plus milbemycin oxime, baclofen and tadalafil, carbamate, methamphetamine, dextroamphetamine sulfate, amlodipine, bromethalin, and organophosphate. The two patients who died were intoxicated with bromethalin and an organophosphate. Six of the 10 patients developed lipemia secondary to ILE administration, and there were no other known adverse effects. Overall, ILE was a safe therapeutic option. This case series provides clinical evidence of successful treatment with ILE as an antidote for previously unpublished toxicities (amlodipine, carbamate, methamphetamine, and dextroamphetamine sulfate), additional evidence of success in treating baclofen and ivermectin toxicosis, as well as unsuccessful treatment of bromethalin and organophosphate toxicities.Keywords: intravenous lipid emulsion, toxicity, amlodipine 
format article
author Becker MD
Young BC
author_facet Becker MD
Young BC
author_sort Becker MD
title Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014)
title_short Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014)
title_full Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014)
title_fullStr Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014)
title_full_unstemmed Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014)
title_sort treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011–2014)
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/182b3400a8c643b688b7599fde96146f
work_keys_str_mv AT beckermd treatmentofseverelipophilicintoxicationswithintravenouslipidemulsionacaseseries2011ndash2014
AT youngbc treatmentofseverelipophilicintoxicationswithintravenouslipidemulsionacaseseries2011ndash2014
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