Puerarin ameliorated the behavioral deficits induced by chronic stress in rats

Abstract The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of puerarin via the chronic unpredictable stress (CUS) procedure in rats. Similar to Sertraline (Ser), Chronic treatment of puerarin (60 and 120 mg/kg, i.g) elicited the antidepressant-like effe...

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Autores principales:	Zhi-Kun Qiu, Guan-Hua Zhang, De-Sheng Zhong, Jia-Li He, Xu Liu, Ji-Sheng Chen, Da-Nian Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/182c9a0d94774ed3a87f068d6653ee66
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spelling	oai:doaj.org-article:182c9a0d94774ed3a87f068d6653ee662021-12-02T11:52:34ZPuerarin ameliorated the behavioral deficits induced by chronic stress in rats10.1038/s41598-017-06552-x2045-2322https://doaj.org/article/182c9a0d94774ed3a87f068d6653ee662017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06552-xhttps://doaj.org/toc/2045-2322Abstract The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of puerarin via the chronic unpredictable stress (CUS) procedure in rats. Similar to Sertraline (Ser), Chronic treatment of puerarin (60 and 120 mg/kg, i.g) elicited the antidepressant-like effects by reversing the decreased sucrose preference in sucrose preference test (SPT), by blocking the increased latency to feed in novelty-suppressed feeding test (NSFT) and the increased immobility time in forced swimming test (FST) without affecting locomotor activity. However, acute puerarin treatment did not ameliorate the antidepressant- and anxiolytic- like effects in FST and NSFT, respectively. In addition, enzyme linked immunosorbent assay (ELISA) and high performance liquid chromatography-electrochemical detection (HPLC-ECD) showed that chronic treatment of puerarin (60 and 120 mg/kg, i.g) reversed the decreased levels of progesterone, allopregnanolone, serotonin (5-HT) and 5-Hydroxyindoleacetic acid (5-HIAA) in prefrontal cortex and hippocampus of post-CUS rats. Furthermore, puerarin (60 and 120 mg/kg, i.g) blocked the increased corticotropin releasing hormone (CRH), corticosterone (Cort) and adrenocorticotropic hormone (ACTH). Collectively, repeated administration of puerarin alleviated the behavioral deficits induced by chronic stress which was associated with the biosynthesis of neurosteroids, normalization of serotonergic system and preventing HPA axis dysfunction.Zhi-Kun QiuGuan-Hua ZhangDe-Sheng ZhongJia-Li HeXu LiuJi-Sheng ChenDa-Nian WeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhi-Kun Qiu Guan-Hua Zhang De-Sheng Zhong Jia-Li He Xu Liu Ji-Sheng Chen Da-Nian Wei Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
description	Abstract The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of puerarin via the chronic unpredictable stress (CUS) procedure in rats. Similar to Sertraline (Ser), Chronic treatment of puerarin (60 and 120 mg/kg, i.g) elicited the antidepressant-like effects by reversing the decreased sucrose preference in sucrose preference test (SPT), by blocking the increased latency to feed in novelty-suppressed feeding test (NSFT) and the increased immobility time in forced swimming test (FST) without affecting locomotor activity. However, acute puerarin treatment did not ameliorate the antidepressant- and anxiolytic- like effects in FST and NSFT, respectively. In addition, enzyme linked immunosorbent assay (ELISA) and high performance liquid chromatography-electrochemical detection (HPLC-ECD) showed that chronic treatment of puerarin (60 and 120 mg/kg, i.g) reversed the decreased levels of progesterone, allopregnanolone, serotonin (5-HT) and 5-Hydroxyindoleacetic acid (5-HIAA) in prefrontal cortex and hippocampus of post-CUS rats. Furthermore, puerarin (60 and 120 mg/kg, i.g) blocked the increased corticotropin releasing hormone (CRH), corticosterone (Cort) and adrenocorticotropic hormone (ACTH). Collectively, repeated administration of puerarin alleviated the behavioral deficits induced by chronic stress which was associated with the biosynthesis of neurosteroids, normalization of serotonergic system and preventing HPA axis dysfunction.
format	article
author	Zhi-Kun Qiu Guan-Hua Zhang De-Sheng Zhong Jia-Li He Xu Liu Ji-Sheng Chen Da-Nian Wei
author_facet	Zhi-Kun Qiu Guan-Hua Zhang De-Sheng Zhong Jia-Li He Xu Liu Ji-Sheng Chen Da-Nian Wei
author_sort	Zhi-Kun Qiu
title	Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
title_short	Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
title_full	Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
title_fullStr	Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
title_full_unstemmed	Puerarin ameliorated the behavioral deficits induced by chronic stress in rats
title_sort	puerarin ameliorated the behavioral deficits induced by chronic stress in rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/182c9a0d94774ed3a87f068d6653ee66
work_keys_str_mv	AT zhikunqiu puerarinamelioratedthebehavioraldeficitsinducedbychronicstressinrats AT guanhuazhang puerarinamelioratedthebehavioraldeficitsinducedbychronicstressinrats AT deshengzhong puerarinamelioratedthebehavioraldeficitsinducedbychronicstressinrats AT jialihe puerarinamelioratedthebehavioraldeficitsinducedbychronicstressinrats AT xuliu puerarinamelioratedthebehavioraldeficitsinducedbychronicstressinrats AT jishengchen puerarinamelioratedthebehavioraldeficitsinducedbychronicstressinrats AT danianwei puerarinamelioratedthebehavioraldeficitsinducedbychronicstressinrats
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Puerarin ameliorated the behavioral deficits induced by chronic stress in rats

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